SKAP2 and FRK

Data Source:
BioGRID (protein complementation assay)

		SKAP2	FRK
Description		src kinase associated phosphoprotein 2	fyn related Src family tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Extracellular Region Intracellular Anatomical Structure Nucleus Nucleoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cell Differentiation Neutrophil Degranulation Innate Immune Response
Pathways		Signal regulatory protein family interactions	Neutrophil degranulation Regulation of PTEN stability and activity
Drugs			Dasatinib Regorafenib Fostamatinib Zanubrutinib
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Disease free survival in colon cancer ( 31811950) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Monocyte count ( 32888494) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Survival in colon cancer ( 31811950) Systemic lupus erythematosus ( 28714469)	Age-related macular degeneration ( 21665990) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 28724990) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Choroid plexus volume ( 31530798) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 27841878) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 32203549 30698716) HOMA-B (corrected for HOMA-IR) ( 30369944) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 32203549 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longevity ( 30294719) Low density lipoprotein cholesterol levels ( 32154731) Photic sneeze reflex ( 27182965) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Urate levels ( 23263486)
Interacting Genes		20 interacting genes: APP BLK DNAJB6 FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1	6 interacting genes: BNIP2 EGFR KHDRBS1 RB1 SF3B4 SKAP2
Entrez ID		8935	2444
HPRD ID		05558	05954
Ensembl ID		ENSG00000005020	ENSG00000111816
Uniprot IDs		B7Z5R3 O75563	P42685
PDB IDs		3OMH
Enriched GO Terms of Interacting Partners?
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