DNAJB6 and KRT18

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DNAJB6	KRT18
Description		DnaJ heat shock protein family (Hsp40) member B6	keratin 18
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Membrane Z Disc Perinuclear Region Of Cytoplasm	Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Intermediate Filament Adherens Junction External Side Of Plasma Membrane Protein-containing Complex Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	ATPase Activator Activity Protein Binding Heat Shock Protein Binding Unfolded Protein Binding Chaperone Binding	RNA Binding Structural Molecule Activity Protein Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Protein Folding Positive Regulation Of ATPase Activity Regulation Of Protein Localization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intermediate Filament Organization Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat	Cell Cycle Anatomical Structure Morphogenesis Response To Fructose Viral Process Keratinization Response To Nutrient Levels Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Cornification Hepatocyte Differentiation Mesenchymal Stem Cell Differentiation Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Cell-cell Adhesion Cholangiocyte Apoptotic Process
Pathways		Regulation of HSF1-mediated heat shock response	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Body mass index ( 28552196) Retinal detachment or retinal break ( 31816047) Waist circumference ( 28552196)	Cleft lip with or without cleft palate ( 28054174) Diffusing capacity of carbon monoxide ( 30694715) Nonsyndromic cleft lip with cleft palate ( 28232668)
Interacting Genes		23 interacting genes: ANKRD1 APP ASAP1 BRMS1 CAND2 DYSF KRT18 MAP3K1 MLF1 MLF2 MRTO4 MYBPC1 MYOM1 PGM1 PIK3CA POLR1D PTEN SGCG SKAP2 SUPT6H TTN TUBGCP3 USP8	91 interacting genes: BBS1 BBS2 BBS4 BBS7 C1orf109 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCHCR1 CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EFHC1 EGFR EP300 ESR1 EXOC8 FRAT1 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 HSPB1 IKBKG KIFC3 KPNA2 KRT15 KRT5 KRT6A KRT6C KRT71 KRT72 KRT79 KRT8 KRT81 LDOC1 LINC01554 MAPK14 NEFL NME7 ORC5 PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE PSTPIP2 RAF1 RCOR3 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SVIL SYCE1 TCHP TEKT4 TNFRSF1B TRADD TSG101 TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A WBP2 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		10049	3875
HPRD ID		07107	01020
Ensembl ID		ENSG00000105993	ENSG00000111057
Uniprot IDs		A0A0J9YX62 O75190	A0A024RAY2 P05783
PDB IDs		6U3R 6U3S
Enriched GO Terms of Interacting Partners?
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