CDK5R1 and NOTCH2NLA

Data Source:
BioGRID (two hybrid)

		CDK5R1	NOTCH2NLA
Description		cyclin dependent kinase 5 regulatory subunit 1	notch 2 N-terminal like A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm Presynapse	Extracellular Region Cytoplasm
	Molecular Function	Protease Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Microtubule Polymerization Neuron Projection Development Activation Of Protein Kinase Activity Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Serine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Regulation Of Synaptic Vesicle Cycle Regulation Of Signal Transduction By P53 Class Mediator	Notch Signaling Pathway Cerebral Cortex Development Cell Differentiation Positive Regulation Of Notch Signaling Pathway
Pathways		CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5
Drugs		Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS
Interacting Genes		31 interacting genes: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 TSC22D4 TTBK1	357 interacting genes: ACY3 ADAM12 ADAMTSL3 ADAMTSL4 ADAMTSL5 ADCK5 AGXT ALDH16A1 ALDH3B1 ALPI ALPP ANKS1A AQP1 AQP5 ARID3A ASPSCR1 ATG9A ATP5F1D BCAM BCL6B BLCAP BMP7 BRME1 C11orf87 C5orf60 CA6 CARHSP1 CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CELF5 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A CNNM3 COL8A1 CRACR2A CRCT1 CREB5 CRH CRY2 CSF1 CST2 CST9L CTNNBIP1 CTSG CTSZ CXCL16 CXCL5 CYHR1 CYP21A2 CYSRT1 DAGLB DALRD3 DBH DGCR6 DGKQ DHRS1 DMRT3 DNAL4 DOCK2 DRD5 EFNA3 EIF4E2 ELANE EMC7 EPHB6 ESR2 F10 FAAH FADS2 FAM124B FAM221A FAM71C FAM71E2 FAM74A4 FAM90A1 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 FTHL17 FZD10 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 H2AC15 HAPLN2 HBA1 HBA2 HBZ HCK HHEX HOXA1 HOXB9 HOXC8 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL10 IL2RG INO80B INPP5D INS ITGB2 ITGB4 ITGB5 JOSD1 KCNS2 KCTD15 KIF1A KLHL38 KLK8 KPRP KRT20 KRT83 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP13-3 KRTAP13-4 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LIMS2 LIN7A LINC00526 LINC00656 LMNTD2 LMO2 LNX1 LONRF3 LRCH4 LRFN4 LYVE1 MACO1 MAPKBP1 MARK4 MATN3 MELTF MFSD13A MOS MRGBP MRPL40 MTA1 MVP MXD3 MXI1 MYO15B MYPOP NAB2 NAXD NECTIN2 NECTIN3 NEDD9 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NTM NTN4 NUBP2 OLFM2 OTX1 P2RX4 P2RX7 P2RY6 PCED1A PCED1B PCSK5 PDE9A PGAP6 PGLS PHLDA1 PID1 PIGS PLEKHN1 PLPP2 PLSCR4 POLR2G POM121L8P POMGNT2 PRF1 PRKAA2 PRPF31 PRPS2 PRR35 PSMA1 PSMG2 PTGER3 PTK7 PTPMT1 PTPN23 PVR QPRT R3HDM2 RAB3IL1 RAMP3 RASD1 RCHY1 RECK RET RGL2 RNF111 RPS19BP1 RPS28 RTN4RL1 SCNM1 SDCBP SELENOM SEMA3B SEMA4C SHFL SLC22A23 SLC22A5 SLC23A1 SLC25A10 SLC25A6 SLC43A2 SLC5A5 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA24 SPATA8 SPG7 SPINK2 SPPL2C SPRY1 STAC STK16 TAPBPL TBC1D10C TBC1D16 TCAF1 TEDC2 THAP7 THEMIS2 TINAGL1 TLE5 TMEFF2 TMEM150A TMEM231 TMEM41A TMIE TNIP3 TNK2 TNP2 TNS2 TRAPPC14 TRIM27 TRIM42 TROAP TRPV6 TSPAN4 TTPA TXNDC5 UBQLN4 UTP23 UXT VASN WDR25 WT1-AS XCL2 YIPF3 ZDHHC1 ZFYVE21 ZNF124 ZNF319 ZNF32 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF446 ZNF497 ZNF580 ZNF581 ZNF587 ZNF648 ZNF672 ZNF688 ZNF786 ZNF837
Entrez ID		8851	388677
HPRD ID		04586	14833
Ensembl ID		ENSG00000176749	ENSG00000264343
Uniprot IDs		Q15078 Q8N619	P0DPK4 Q7Z3S9
PDB IDs		1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG
Enriched GO Terms of Interacting Partners?
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