Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
CDK5R1 and CAMK2A
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo, two hybrid)
CDK5R1
CAMK2A
Description
cyclin dependent kinase 5 regulatory subunit 1
calcium/calmodulin dependent protein kinase II alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Perikaryon
Intracellular Membrane-bounded Organelle
Contractile Fiber
Perinuclear Region Of Cytoplasm
Presynapse
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Calcium- And Calmodulin-dependent Protein Kinase Complex
Postsynaptic Density
Endocytic Vesicle Membrane
Neuron Projection
Dendritic Spine
Molecular Function
Protease Binding
Protein Kinase Activity
Calcium Ion Binding
Protein Binding
Kinase Activity
Protein Kinase Binding
Protein Kinase Activator Activity
Ionotropic Glutamate Receptor Binding
Alpha-tubulin Binding
Protein Serine/threonine Kinase Activator Activity
Cadherin Binding
Ephrin Receptor Binding
Beta-tubulin Binding
Actin Filament Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Protein Serine/threonine Kinase Activity
Calmodulin-dependent Protein Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Calcium-dependent Protein Serine/threonine Kinase Activity
Kinase Activity
Glutamate Receptor Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Microtubule Cytoskeleton Organization
Neuron Migration
Neuron Cell-cell Adhesion
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Axon Guidance
Axonal Fasciculation
Brain Development
Embryo Development Ending In Birth Or Egg Hatching
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cerebellum Development
Superior Olivary Nucleus Maturation
Hippocampus Development
Layer Formation In Cerebral Cortex
Neuron Differentiation
Negative Regulation Of Axon Extension
Positive Regulation Of Microtubule Polymerization
Neuron Projection Development
Activation Of Protein Kinase Activity
Regulation Of Actin Cytoskeleton Organization
Ionotropic Glutamate Receptor Signaling Pathway
Serine Phosphorylation Of STAT Protein
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Ephrin Receptor Signaling Pathway
Rhythmic Process
Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Cell Cycle Arrest
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Synaptic Vesicle Cycle
Regulation Of Signal Transduction By P53 Class Mediator
G1/S Transition Of Mitotic Cell Cycle
Response To Ischemia
Protein Phosphorylation
Calcium Ion Transport
Wnt Signaling Pathway, Calcium Modulating Pathway
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Peptidyl-serine Phosphorylation
Angiotensin-activated Signaling Pathway
Protein Autophosphorylation
Regulation Of Neurotransmitter Secretion
Regulation Of Neuronal Synaptic Plasticity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Hydrolase Activity
Positive Regulation Of Calcium Ion Transport
Interferon-gamma-mediated Signaling Pathway
Dendritic Spine Development
Regulation Of Cellular Response To Heat
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Peptidyl-threonine Autophosphorylation
Regulation Of Endocannabinoid Signaling Pathway
Regulation Of Neuron Migration
Pathways
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
CaMK IV-mediated phosphorylation of CREB
HSF1-dependent transactivation
Trafficking of AMPA receptors
Ca2+ pathway
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Interferon gamma signaling
Regulation of MECP2 expression and activity
Ion transport by P-type ATPases
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Indirubin-3'-monoxime
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Hexatantalum Dodecabromide
1,4-Dithiothreitol
(2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}
Fostamatinib
Diseases
GWAS
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Inflammatory bowel disease (
28067908
)
Obesity-related traits (
23251661
)
Ulcerative colitis (
28067908
)
Interacting Genes
31 interacting genes:
ACTN1
AMPH
APP
BLOC1S6
CAMK2A
CAPN1
CAPN2
CDK16
CDK5
CDK5RAP1
CDK5RAP2
CDK5RAP3
CDK9
CHN1
CTNNB1
HSP90AA1
KRT40
KRTAP10-3
LMTK2
MTUS2
NEDD4
NES
NOTCH2NLA
ODF1
PAK1
SEPTIN5
SET
SIAH1
STXBP1
TSC22D4
TTBK1
87 interacting genes:
ACTN1
ACTN2
ACTN4
ARID5A
ATF1
ATP2A2
C1orf94
CAMK2B
CAMK2D
CAMK2G
CAMK2N2
CDC37
CDK5R1
CDK5R2
CEBPB
CHAT
CREB1
DAPK2
DAZAP2
DLG1
EGFR
ETS1
FAM168A
FAM168B
GFAP
GLB1L2
GRIA1
GRIN1
GRIN2A
GRIN2B
HSF1
HYAL3
ITGA2B
ITGB1BP1
ITPKA
KRT18
KRT75
KRT76
KRTAP15-1
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP22-1
KRTAP23-1
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP8-1
LASP1
LENG8
LRRC7
MAPT
MPDZ
MRPL11
NOS1
NTAQ1
PDC
PPM1F
PSMC5
PTTG1
RALYL
RBFOX2
RBM47
RBPMS
RBPMS2
RCHY1
RHOXF2
RIMS1
SMAD2
SOX5
SQSTM1
SRF
SUOX
SYNGAP1
TAB2
TANC1
TCAF1
TEX37
TFAP2D
TIAL1
TRIM55
TRIM63
TSR2
TTC5
VARS1
YWHAB
ZBTB32
Entrez ID
8851
815
HPRD ID
04586
06532
Ensembl ID
ENSG00000176749
ENSG00000070808
Uniprot IDs
Q15078
Q8N619
A8K161
Q7LDD5
Q8IWE0
Q9UQM7
PDB IDs
1H4L
1UNG
1UNH
1UNL
3O0G
6LDP
7CNG
2VZ6
3SOA
5IG3
6OF8
6VZK
6W4O
6W4P
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?