TNFRSF10B and TNFRSF10D

Data Source:
HPRD (in vivo, in vitro)

		TNFRSF10B	TNFRSF10D
Description		TNF receptor superfamily member 10b	TNF receptor superfamily member 10d
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity TRAIL Binding	Transmembrane Signaling Receptor Activity Protein Binding TRAIL Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Leukocyte Migration Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Leukocyte Migration
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling	Cell surface interactions at the vascular wall TP53 Regulates Transcription of Death Receptors and Ligands TRAIL signaling
Drugs		HGS-TR2J Lexatumumab
Diseases
GWAS		Blood protein levels ( 30072576) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Renal cell carcinoma ( 28598434)	Attention deficit hyperactivity disorder ( 20732625) Lymphocyte percentage of white cells ( 32888494)
Interacting Genes		15 interacting genes: ASPH CASP8 CDC42 CFLAR FADD MADD MUC1 RIPK1 TIMM50 TMEM31 TNFRSF10A TNFRSF10D TNFSF10 TRADD ZDHHC15	28 interacting genes: APOL3 ARFIP1 CIAO2A ECPAS FAM114A1 GAD2 HSBP1L1 INPP5K LAT MIEF1 MTERF4 PCYT1A PITPNC1 PLPP6 POLL RBP1 RMDN2 SEMA4G SENP2 SLC39A7 SUCLA2 TARS2 TBRG4 THAP4 TNFRSF10A TNFRSF10B TNFSF10 TUFM
Entrez ID		8795	8793
HPRD ID		04680	04682
Ensembl ID		ENSG00000120889	ENSG00000173530
Uniprot IDs		O14763 Q7Z2I8	Q9UBN6
PDB IDs		1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2 6NHW 6NHY 6T3J
Enriched GO Terms of Interacting Partners?
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