TNFRSF10B and MADD

Data Source:
HPRD (in vitro, in vivo)

		TNFRSF10B	MADD
Description		TNF receptor superfamily member 10b	MAP kinase activating death domain
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Cytoplasm Cytosol Plasma Membrane Integral Component Of Membrane Synapse
	Molecular Function	Protein Binding Signaling Receptor Activity TRAIL Binding	Guanyl-nucleotide Exchange Factor Activity Death Receptor Binding Protein Binding Protein Kinase Activator Activity
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Leukocyte Migration Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Activation Of MAPK Activity Cell Surface Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
Drugs		HGS-TR2J Lexatumumab
Diseases
GWAS		Blood protein levels ( 30072576) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Renal cell carcinoma ( 28598434)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) C-reactive protein levels ( 30388399) Chronic kidney disease ( 26831199) Chronotype ( 30696823) Corneal astigmatism ( 29422769) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 29891935) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol ( 19060911 25961943) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Insulin-related traits (multivariate analysis) ( 32002517) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Monocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Proinsulin levels ( 21873549) Refractive error ( 32231278)
Interacting Genes		15 interacting genes: ASPH CASP8 CDC42 CFLAR FADD MADD MUC1 RIPK1 TIMM50 TMEM31 TNFRSF10A TNFRSF10D TNFSF10 TRADD ZDHHC15	10 interacting genes: NPDC1 PIDD1 POT1 PTPRN RB1CC1 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ
Entrez ID		8795	8567
HPRD ID		04680	04664
Ensembl ID		ENSG00000120889	ENSG00000110514
Uniprot IDs		O14763 Q7Z2I8	A0A0A0MRB5 Q8WXG6
PDB IDs		1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2 6NHW 6NHY 6T3J
Enriched GO Terms of Interacting Partners?
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