TNFRSF10D and GAD2

Data Source:
BioGRID (two hybrid)

		TNFRSF10D	GAD2
Description		TNF receptor superfamily member 10d	glutamate decarboxylase 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Golgi Membrane Cytosol Plasma Membrane Axon Synaptic Vesicle Membrane Anchored Component Of Membrane Presynaptic Membrane Perinuclear Region Of Cytoplasm Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding TRAIL Binding	Glutamate Decarboxylase Activity Protein Binding Glutamate Binding Pyridoxal Phosphate Binding Protein-containing Complex Binding
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Leukocyte Migration	Glutamate Decarboxylation To Succinate Chemical Synaptic Transmission Neurotransmitter Secretion Neurotransmitter Biosynthetic Process Response To Drug
Pathways		Cell surface interactions at the vascular wall TP53 Regulates Transcription of Death Receptors and Ligands TRAIL signaling	GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal phosphate Glutamic acid
Diseases
GWAS		Attention deficit hyperactivity disorder ( 20732625) Lymphocyte percentage of white cells ( 32888494)	Lean body mass ( 28552196)
Interacting Genes		28 interacting genes: APOL3 ARFIP1 CIAO2A ECPAS FAM114A1 GAD2 HSBP1L1 INPP5K LAT MIEF1 MTERF4 PCYT1A PITPNC1 PLPP6 POLL RBP1 RMDN2 SEMA4G SENP2 SLC39A7 SUCLA2 TARS2 TBRG4 THAP4 TNFRSF10A TNFRSF10B TNFSF10 TUFM	45 interacting genes: ABHD5 AGTRAP APOC2 APOC4 ARL13B ARL6IP1 ARMC12 BSND CACNG1 CMTM5 CPLX4 CYB561D1 DERL1 DERL3 DGAT2L6 DMKN F10 FADS6 FAM114A2 FAM163A GAD1 HIGD1C LIME1 MAL2 MEST MRM3 PBX3 PLIN3 PRKACA PRKCE RDH10 RHEX RPRM SCAMP1 SDR16C5 SEC22A SMPD2 SPG21 SYCE2 SYNGR3 TMEM120B TMEM128 TMEM159 TNFRSF10D TSPAN33
Entrez ID		8793	2572
HPRD ID		04682	11817
Ensembl ID		ENSG00000173530	ENSG00000136750
Uniprot IDs		Q9UBN6	Q05329 Q5VZ30
PDB IDs			1ES0 2OKK
Enriched GO Terms of Interacting Partners?
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