TNFRSF10D and LAT

Data Source:
BioGRID (two hybrid)

		TNFRSF10D	LAT
Description		TNF receptor superfamily member 10d	linker for activation of T cells
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Immunological Synapse Golgi Apparatus Plasma Membrane COP9 Signalosome Integral Component Of Membrane Membrane Raft
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding TRAIL Binding	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Leukocyte Migration	MAPK Cascade Adaptive Immune Response Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		Cell surface interactions at the vascular wall TP53 Regulates Transcription of Death Receptors and Ligands TRAIL signaling	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 20732625) Lymphocyte percentage of white cells ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		28 interacting genes: APOL3 ARFIP1 CIAO2A ECPAS FAM114A1 GAD2 HSBP1L1 INPP5K LAT MIEF1 MTERF4 PCYT1A PITPNC1 PLPP6 POLL RBP1 RMDN2 SEMA4G SENP2 SLC39A7 SUCLA2 TARS2 TBRG4 THAP4 TNFRSF10A TNFRSF10B TNFSF10 TUFM	95 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MFSD14B MFSD5 MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35C2 SLC51B SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2
Entrez ID		8793	27040
HPRD ID		04682	03832
Ensembl ID		ENSG00000173530	ENSG00000213658
Uniprot IDs		Q9UBN6	A0A024QZD6 O43561
PDB IDs
Enriched GO Terms of Interacting Partners?
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