CBS and VTA1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CBS	VTA1
Description		cystathionine beta-synthase	vesicle trafficking 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Multivesicular Body Cytosol Endosome Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Cystathionine Beta-synthase Activity Protein Binding Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process DNA Protection Homocysteine Catabolic Process Homocysteine Metabolic Process Hydrogen Sulfide Biosynthetic Process	Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Multivesicular Body Sorting Pathway ESCRT III Complex Disassembly
Pathways		Cysteine formation from homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs		Pyridoxal phosphate Ademetionine Serine Cysteine
Diseases		Homocystinuria
GWAS		Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Homocysteine levels ( 23824729 20031578) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Plasma homocysteine levels (post-methionine load test) ( 24651765) Pre-treatment viral load in HIV-1 infection ( 31219150)	Chronic obstructive pulmonary disease ( 30804561) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) FEV1 ( 30804560) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Retinal vascular caliber ( 21060863)
Interacting Genes		23 interacting genes: CBX4 CERT1 DAXX EHHADH FXR2 HGS HID1 HTT NTAQ1 PIAS1 PIAS2 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 UBASH3A UBE2I UGP2 VTA1 ZDHHC17 ZMYM5	22 interacting genes: APP BEX3 CBS CCNC CDK4 CHMP1A CHMP1B CHMP5 DPPA2 ERBB3 KCTD13 KLHL12 LYST MAGEA11 MBIP NBR1 NECAB2 RABAC1 RPIA TEAD4 ZBTB16 ZNRD2
Entrez ID		875	51534
HPRD ID		01994	09855
Ensembl ID		ENSG00000160200	ENSG00000009844
Uniprot IDs		B7Z2D6 P0DN79 P35520 Q9NTF0	A0A087WY55 Q9NP79
PDB IDs		1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS	2LXL 2LXM 4TXP 4TXQ 4TXR 4U7E
Enriched GO Terms of Interacting Partners?
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