CBS and UGP2

Data Source:
BioGRID (two hybrid)

		CBS	UGP2
Description		cystathionine beta-synthase	UDP-glucose pyrophosphorylase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Cystathionine Beta-synthase Activity Protein Binding Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding	UTP:glucose-1-phosphate Uridylyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process DNA Protection Homocysteine Catabolic Process Homocysteine Metabolic Process Hydrogen Sulfide Biosynthetic Process	Glycogen Metabolic Process Glycogen Biosynthetic Process UDP-glucose Metabolic Process UDP-glucuronate Biosynthetic Process Brain Development
Pathways		Cysteine formation from homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Formation of the active cofactor, UDP-glucuronate Glycogen synthesis
Drugs		Pyridoxal phosphate Ademetionine Serine Cysteine
Diseases		Homocystinuria
GWAS		Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Homocysteine levels ( 23824729 20031578) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Plasma homocysteine levels (post-methionine load test) ( 24651765) Pre-treatment viral load in HIV-1 infection ( 31219150)	Clozapine-induced agranulocytosis ( 25187353) Smoking initiation (ever regular vs never regular) ( 30679032) Systolic blood pressure ( 26969751)
Interacting Genes		23 interacting genes: CBX4 CERT1 DAXX EHHADH FXR2 HGS HID1 HTT NTAQ1 PIAS1 PIAS2 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 UBASH3A UBE2I UGP2 VTA1 ZDHHC17 ZMYM5	7 interacting genes: ABCA1 ARIH2 CBS GLRX3 PCBP1 PLEKHF2 TTN
Entrez ID		875	7360
HPRD ID		01994	08934
Ensembl ID		ENSG00000160200	ENSG00000169764
Uniprot IDs		B7Z2D6 P0DN79 P35520 Q9NTF0	A0A140VKE1 Q16851
PDB IDs		1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS	3R2W 3R3I 4R7P
Enriched GO Terms of Interacting Partners?
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