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KRT37 and PKN1
Data Source:
BioGRID
(two hybrid)
KRT37
PKN1
Description
keratin 37
protein kinase N1
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Intermediate Filament
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Midbody
Cleavage Furrow
Protein-containing Complex
Molecular Function
Structural Molecule Activity
Protein Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Nuclear Receptor Coactivator Activity
Small GTPase Binding
Histone Kinase Activity (H3-T11 Specific)
Histone Binding
Histone Deacetylase Binding
Androgen Receptor Binding
Biological Process
Keratinization
Cornification
B Cell Homeostasis
B Cell Apoptotic Process
Regulation Of Germinal Center Formation
Regulation Of Immunoglobulin Production
Renal System Process
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Signal Transduction
Activation Of JUN Kinase Activity
Epithelial Cell Migration
Peptidyl-serine Phosphorylation
Negative Regulation Of B Cell Proliferation
Histone H3-T11 Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Transcription, DNA-templated
Spleen Development
Regulation Of Cell Motility
Pathways
Keratinization
Formation of the cornified envelope
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Fostamatinib
Diseases
GWAS
Squamous cell lung carcinoma (
28604730
)
Pancreatic cancer (
30206226
)
Urolithiasis (
30975718
)
Interacting Genes
41 interacting genes:
AGXT
AQP1
BCAS2
BFSP2
C21orf58
CCDC196
CLCNKA
COL8A1
DES
FAM110A
FBXW5
GNG13
HAPLN2
HGS
HOXA1
HSF4
KRT1
KRT3
KRT4
KRT6B
KRT6C
KRT71
KRT74
KRT75
KRT76
KRT81
KRT83
KRT85
KRT86
MTG1
NUFIP2
OIP5
OTX1
PIN1
PKN1
PSMA1
SMARCD1
SMARCE1
TBC1D21
TXLNB
USHBP1
83 interacting genes:
ACTN1
ADAMTSL4
AKAP9
ARHGAP10
ARHGAP26
ARSA
BLZF1
BUD23
CASP3
CCDC103
CCDC136
CCDC138
CCDC85B
CCNT2
CD44
CDC25C
CDR2
CEP57
CEP57L1
CEP70
CYSRT1
DISC1
DYDC1
EIF3F
GOLGA2
GOLGA6L9
H3C14
HAP1
HAUS1
HDAC5
HOMER3
HSF2BP
INTS11
KIAA1328
KRT15
KRT16
KRT19
KRT31
KRT34
KRT35
KRT36
KRT37
LRRC61
MAP2K6
MAPK12
MAPT
MARCKS
MBP
MID1
MID2
MIPOL1
MKRN3
MTDH
MTUS2
NEFH
NEFL
NEUROD2
PDPK1
PICK1
PLD1
PNMA1
POU6F2
PSMB4
RAB3IP
RHOA
SERTAD3
SMYD3
SPAG5
SPRR2D
SSX2IP
STX11
SYCE3
TNFRSF1B
TRAF1
TRAF2
TRIM27
TSGA10
UBR2
USHBP1
VIM
ZFAND6
ZNF282
ZRANB1
Entrez ID
8688
5585
HPRD ID
05175
03019
Ensembl ID
ENSG00000108417
ENSG00000123143
Uniprot IDs
O76014
Q16512
PDB IDs
1CXZ
1URF
2RMK
4NKG
4OTD
4OTG
4OTH
4OTI
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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