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BECN1 and MAP2K3
Data Source:
BioGRID
(fluorescent resonance energy transfer, fluorescent resonance energy transfer, affinity chromatography technology)
BECN1
MAP2K3
Description
beclin 1
mitogen-activated protein kinase kinase 3
Image
No pdb structure
GO Annotations
Cellular Component
Phagophore Assembly Site
Nucleus
Mitochondrion
Endosome
Autophagosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Trans-Golgi Network
Cytosol
Endosome Membrane
Extrinsic Component Of Membrane
Dendrite
Mitochondrial Membrane
Phosphatidylinositol 3-kinase Complex, Class III, Type I
Phosphatidylinositol 3-kinase Complex, Class III, Type II
Phosphatidylinositol 3-kinase Complex, Class III
Phagocytic Vesicle
Nucleoplasm
Cytosol
Membrane
Molecular Function
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
GTPase Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Biological Process
Autophagosome Assembly
Autophagy Of Mitochondrion
Mitophagy
Response To Hypoxia
Autophagy
Apoptotic Process
Cellular Defense Response
Cellular Response To Nitrogen Starvation
Lysosome Organization
Mitotic Metaphase Plate Congression
Aging
Negative Regulation Of Cell Population Proliferation
Response To Iron(II) Ion
Response To Lead Ion
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Macroautophagy
Protein Deubiquitination
Regulation Of Cytokinesis
Receptor Catabolic Process
Response To Vitamin E
Cellular Response To Amino Acid Starvation
Cellular Response To Glucose Starvation
Response To Drug
Negative Regulation Of Apoptotic Process
Engulfment Of Apoptotic Cell
Early Endosome To Late Endosome Transport
Late Endosome To Vacuole Transport
Neuron Development
Amyloid-beta Metabolic Process
Regulation Of Catalytic Activity
Cell Division
Defense Response To Virus
Negative Regulation Of Cell Death
Cellular Response To Hydrogen Peroxide
Cellular Response To Aluminum Ion
Cellular Response To Copper Ion
Cellular Response To Epidermal Growth Factor Stimulus
Response To Mitochondrial Depolarisation
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Lysosome Organization
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Autophagosome Assembly
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Activation Of MAPK Activity
Regulation Of Cytokine Production
Inflammatory Response
Signal Transduction
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Hippo Signaling
Cellular Response To Vascular Endothelial Growth Factor Stimulus
P38MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Cardiac Muscle Contraction
Pathways
Macroautophagy
Ub-specific processing proteases
Translation of Replicase and Assembly of the Replication Transcription Complex
Translation of Replicase and Assembly of the Replication Transcription Complex
Oxidative Stress Induced Senescence
activated TAK1 mediates p38 MAPK activation
Drugs
Estradiol
Estradiol acetate
Estradiol benzoate
Estradiol cypionate
Estradiol dienanthate
Estradiol valerate
Fostamatinib
Diseases
GWAS
Type 2 diabetes (age of onset) (
28060188
)
Body mass index (
26426971
28892062
)
Interacting Genes
59 interacting genes:
AKT1
AMBRA1
ARAF
ARNT
ATG3
BCL2
BCL2L1
BCL2L10
BTK
CASP3
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
EPHA2
ERBB2
FGFR4
FRS2
FZR1
GFI1B
GLIS2
GOPC
GRM1
HERC5
ITCH
ITPR1
ITPR3
KAT2A
KDELR2
LATS2
MAP2K3
MAP2K5
MAP2K6
MAPKAPK2
MAPKAPK3
MDM4
MST1
NF2
NXF1
PDGFRA
PGK1
RACK1
RAF1
SENP3
SGF29
SHD
SMAD2
STK11
STYK1
TEAD2
TERT
TRAF2
TSC1
UBC
ULK1
WASHC1
XPO1
YES1
54 interacting genes:
AKT1
ALDOC
APP
ARAF
ARRB1
AURKA
BECN1
BRAF
CBLC
CCND2
CD44
CDC42
CDK4
CDK6
CDKN2B
CDKN2C
DCTN1
DYRK1B
ELK1
ERBB2
FZR1
GLIS2
HIF1A
KAT2A
KDELR2
LATS2
LRRK2
MAP2K5
MAP2K6
MAP3K2
MAP3K3
MAP3K4
MAPK12
MAPK14
MAPK3
MAPK8IP2
MET
NF1
NF2
NFIC
PLCB2
PTEN
RAF1
RASSF1
RPL13
SMAD1
SMAD7
STK11
TAOK1
TAOK2
TEAD2
TERT
TINF2
TP53
Entrez ID
8678
5606
HPRD ID
05087
03816
Ensembl ID
ENSG00000126581
ENSG00000034152
Uniprot IDs
A0A024R1X5
B4DQ36
E7EV84
Q14457
W0FFG4
P46734
Q6FI23
PDB IDs
2P1L
2PON
3DVU
4DDP
4MI8
5EFM
5HHE
5VAU
5VAX
5VAY
6DCN
6DCO
6HOI
6HOJ
6HOK
Enriched GO Terms of Interacting Partners
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