BECN1 and EPHA2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		BECN1	EPHA2
Description		beclin 1	EPH receptor A2
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleus Mitochondrion Endosome Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Trans-Golgi Network Cytosol Endosome Membrane Extrinsic Component Of Membrane Dendrite Mitochondrial Membrane Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Lamellipodium Leading Edge Membrane Lamellipodium Membrane Ruffle Membrane Neuron Projection Receptor Complex Tight Junction
	Molecular Function	Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding GTPase Binding	Virus Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Response To Hypoxia Autophagy Apoptotic Process Cellular Defense Response Cellular Response To Nitrogen Starvation Lysosome Organization Mitotic Metaphase Plate Congression Aging Negative Regulation Of Cell Population Proliferation Response To Iron(II) Ion Response To Lead Ion Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Macroautophagy Protein Deubiquitination Regulation Of Cytokinesis Receptor Catabolic Process Response To Vitamin E Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Response To Drug Negative Regulation Of Apoptotic Process Engulfment Of Apoptotic Cell Early Endosome To Late Endosome Transport Late Endosome To Vacuole Transport Neuron Development Amyloid-beta Metabolic Process Regulation Of Catalytic Activity Cell Division Defense Response To Virus Negative Regulation Of Cell Death Cellular Response To Hydrogen Peroxide Cellular Response To Aluminum Ion Cellular Response To Copper Ion Cellular Response To Epidermal Growth Factor Stimulus Response To Mitochondrial Depolarisation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Negative Regulation Of Autophagosome Assembly Negative Regulation Of Lysosome Organization Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Autophagosome Assembly Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Skeletal System Development Vasculogenesis Osteoblast Differentiation Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Inflammatory Response Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Lamellipodium Assembly Notochord Formation Cell Migration Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Neural Tube Development Keratinocyte Differentiation Osteoclast Differentiation Negative Regulation Of Chemokine Production Mammary Gland Epithelial Cell Proliferation Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Post-anal Tail Morphogenesis Protein Kinase B Signaling Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis CAMP Metabolic Process Viral Entry Into Host Cell Bone Remodeling Ephrin Receptor Signaling Pathway Axial Mesoderm Formation Cell Motility Defense Response To Gram-positive Bacterium Negative Regulation Of Protein Kinase B Signaling Notochord Cell Development Cell Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Lens Fiber Cell Morphogenesis Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Protein Localization To Plasma Membrane Activation Of GTPase Activity Negative Regulation Of Lymphangiogenesis Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Bicellular Tight Junction Assembly Pericyte Cell Differentiation
Pathways		Macroautophagy Ub-specific processing proteases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate	Dasatinib Phosphoaminophosphonic Acid-Adenylate Ester Regorafenib Fostamatinib
Diseases
GWAS		Type 2 diabetes (age of onset) ( 28060188)	Blood protein levels ( 30072576) Gamma glutamyl transferase levels ( 29403010) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757)
Interacting Genes		59 interacting genes: AKT1 AMBRA1 ARAF ARNT ATG3 BCL2 BCL2L1 BCL2L10 BTK CASP3 CCND2 CDK4 CDK6 CDKN2A CDKN2B EPHA2 ERBB2 FGFR4 FRS2 FZR1 GFI1B GLIS2 GOPC GRM1 HERC5 ITCH ITPR1 ITPR3 KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAPKAPK2 MAPKAPK3 MDM4 MST1 NF2 NXF1 PDGFRA PGK1 RACK1 RAF1 SENP3 SGF29 SHD SMAD2 STK11 STYK1 TEAD2 TERT TRAF2 TSC1 UBC ULK1 WASHC1 XPO1 YES1	84 interacting genes: ABCB5 ACP1 AKT1 APP ARAF ARNT AURKA BECN1 CBL CBLC CCND2 CD44 CDC42 CDH5 CDK17 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CLDN4 DUSP14 DUSP18 DUSP19 DUSP26 DUSP29 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGFR ERBB2 FGFR4 FZR1 GATAD1 GLIS2 GRB2 GRK2 GRM1 HGF HIF1A ILKAP KDELR2 KPNA3 LATS2 LSM7 MAP2K5 MAP2K6 MAPK14 MDM4 MET MSH2 MYC NF1 NF2 NFIC NUDT9 PDGFRA PIK3R1 PIK3R2 PPM1L PSME2 PTEN PTK2 PTPN11 PTPN7 PTPRR RAF1 RASA1 RASSF1 RBL1 RELA SHC1 SLA STK11 STYX TEAD2 TIAM1 TNFAIP1 TP53 TPTE TPTE2 UBE4A
Entrez ID		8678	1969
HPRD ID		05087	01494
Ensembl ID		ENSG00000126581	ENSG00000142627
Uniprot IDs		A0A024R1X5 B4DQ36 E7EV84 Q14457 W0FFG4	A0A024QZA8 P29317
PDB IDs		2P1L 2PON 3DVU 4DDP 4MI8 5EFM 5HHE 5VAU 5VAX 5VAY 6DCN 6DCO 6HOI 6HOJ 6HOK	1MQB 2E8N 2K9Y 2KSO 2X10 2X11 3C8X 3CZU 3FL7 3HEI 3HPN 3KKA 3MBW 3MX0 3SKJ 4P2K 4PDO 4TRL 5EK7 5I9U 5I9V 5I9W 5I9X 5I9Y 5I9Z 5IA0 5IA1 5IA2 5IA3 5IA4 5IA5 5NJZ 5NK0 5NK1 5NK2 5NK3 5NK4 5NK5 5NK6 5NK7 5NK8 5NK9 5NKA 5NKB 5NKC 5NKD 5NKE 5NKF 5NKG 5NKH 5NKI 5NZ9 6B9L 6F7M 6F7N 6FNF 6FNG 6FNH 6HES 6HET 6HEU 6HEV 6HEW 6HEX 6HEY 6NJZ 6NK0 6NK1 6NK2 6NKP 6Q7B 6Q7C 6Q7D 6Q7E 6Q7F 6Q7G 6RW2 7CZE 7CZF
Enriched GO Terms of Interacting Partners?
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