MAP2K3 and ALDOC

Data Source:
BioGRID (two hybrid)

		MAP2K3	ALDOC
Description		mitogen-activated protein kinase kinase 3	aldolase, fructose-bisphosphate C
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Membrane	Extracellular Region Cytosol Cytoskeleton Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cytokine Production Inflammatory Response Signal Transduction Peptidyl-tyrosine Phosphorylation Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction	Fructose Metabolic Process Gluconeogenesis Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Epithelial Cell Differentiation Neutrophil Degranulation Canonical Glycolysis
Pathways		Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation	Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 26426971 28892062)
Interacting Genes		54 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53	7 interacting genes: ANKS1A ATP6V1E1 ERBB2 LNX1 MAP2K3 PLD2 SQLE
Entrez ID		5606	230
HPRD ID		03816	02386
Ensembl ID		ENSG00000034152	ENSG00000109107
Uniprot IDs		P46734 Q6FI23	A0A024QZ64 P09972
PDB IDs			1XFB
Enriched GO Terms of Interacting Partners?
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