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BECN1 and FRS2
Data Source:
BioGRID
(two hybrid)
BECN1
FRS2
Description
beclin 1
fibroblast growth factor receptor substrate 2
Image
GO Annotations
Cellular Component
Phagophore Assembly Site
Nucleus
Mitochondrion
Endosome
Autophagosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Trans-Golgi Network
Cytosol
Endosome Membrane
Extrinsic Component Of Membrane
Dendrite
Mitochondrial Membrane
Phosphatidylinositol 3-kinase Complex, Class III, Type I
Phosphatidylinositol 3-kinase Complex, Class III, Type II
Phosphatidylinositol 3-kinase Complex, Class III
Phagocytic Vesicle
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Adherens Junction
Endomembrane System
Membrane
Molecular Function
Protein Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphatidylinositol 3-kinase Binding
GTPase Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Fibroblast Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phosphatase Activator Activity
Biological Process
Autophagosome Assembly
Autophagy Of Mitochondrion
Mitophagy
Response To Hypoxia
Autophagy
Apoptotic Process
Cellular Defense Response
Cellular Response To Nitrogen Starvation
Lysosome Organization
Mitotic Metaphase Plate Congression
Aging
Negative Regulation Of Cell Population Proliferation
Response To Iron(II) Ion
Response To Lead Ion
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Macroautophagy
Protein Deubiquitination
Regulation Of Cytokinesis
Receptor Catabolic Process
Response To Vitamin E
Cellular Response To Amino Acid Starvation
Cellular Response To Glucose Starvation
Response To Drug
Negative Regulation Of Apoptotic Process
Engulfment Of Apoptotic Cell
Early Endosome To Late Endosome Transport
Late Endosome To Vacuole Transport
Neuron Development
Amyloid-beta Metabolic Process
Regulation Of Catalytic Activity
Cell Division
Defense Response To Virus
Negative Regulation Of Cell Death
Cellular Response To Hydrogen Peroxide
Cellular Response To Aluminum Ion
Cellular Response To Copper Ion
Cellular Response To Epidermal Growth Factor Stimulus
Response To Mitochondrial Depolarisation
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Negative Regulation Of Autophagosome Assembly
Negative Regulation Of Lysosome Organization
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Autophagosome Assembly
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Gastrulation With Mouth Forming Second
Organ Induction
Ventricular Septum Development
Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Neuroblast Proliferation
Axon Guidance
Fibroblast Growth Factor Receptor Signaling Pathway
Anterior/posterior Axis Specification, Embryo
Forebrain Development
Regulation Of Apoptotic Process
Optic Placode Formation Involved In Camera-type Eye Formation
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Kinase B Signaling
Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis
Lens Fiber Cell Development
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Macroautophagy
Ub-specific processing proteases
Translation of Replicase and Assembly of the Replication Transcription Complex
Translation of Replicase and Assembly of the Replication Transcription Complex
PI3K Cascade
PIP3 activates AKT signaling
Frs2-mediated activation
Frs2-mediated activation
Constitutive Signaling by Aberrant PI3K in Cancer
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Drugs
Estradiol
Estradiol acetate
Estradiol benzoate
Estradiol cypionate
Estradiol dienanthate
Estradiol valerate
Diseases
GWAS
Type 2 diabetes (age of onset) (
28060188
)
Complete remission in asthma (
29786918
)
Heel bone mineral density (
30598549
)
Height (
20881960
25282103
25429064
23563607
31562340
18391951
)
Hip circumference adjusted for BMI (
25673412
)
Logical memory (delayed recall) in normal cognition (
29274321
)
Microalbuminuria (
31511532
)
Response to antidepressants (symptom remission) (
29160301
)
Response to diuretic therapy (
18591461
)
Thyroid stimulating hormone levels (
32769997
)
Urinary albumin-to-creatinine ratio (
31511532
)
Interacting Genes
59 interacting genes:
AKT1
AMBRA1
ARAF
ARNT
ATG3
BCL2
BCL2L1
BCL2L10
BTK
CASP3
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
EPHA2
ERBB2
FGFR4
FRS2
FZR1
GFI1B
GLIS2
GOPC
GRM1
HERC5
ITCH
ITPR1
ITPR3
KAT2A
KDELR2
LATS2
MAP2K3
MAP2K5
MAP2K6
MAPKAPK2
MAPKAPK3
MDM4
MST1
NF2
NXF1
PDGFRA
PGK1
RACK1
RAF1
SENP3
SGF29
SHD
SMAD2
STK11
STYK1
TEAD2
TERT
TRAF2
TSC1
UBC
ULK1
WASHC1
XPO1
YES1
28 interacting genes:
BECN1
CBL
CDK3
CRK
DDR1
FGFR1
GAB1
GRB2
INSR
KDR
MAPK1
MAPK3
NCK1
NTRK1
NTRK2
NTRK3
PAK1
PIN1
PRKCI
PRKCZ
PTPN11
PTPRF
RET
RND1
RPS6
SOS1
SRC
YJU2
Entrez ID
8678
10818
HPRD ID
05087
06372
Ensembl ID
ENSG00000126581
ENSG00000166225
Uniprot IDs
A0A024R1X5
B4DQ36
E7EV84
Q14457
W0FFG4
L7RTG7
Q8WU20
PDB IDs
2P1L
2PON
3DVU
4DDP
4MI8
5EFM
5HHE
5VAU
5VAX
5VAY
6DCN
6DCO
6HOI
6HOJ
6HOK
1XR0
2MFQ
Enriched GO Terms of Interacting Partners
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