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MAP2K3 and KAT2A
Data Source:
BioGRID
(fluorescent resonance energy transfer)
MAP2K3
KAT2A
Description
mitogen-activated protein kinase kinase 3
lysine acetyltransferase 2A
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Membrane
Histone Acetyltransferase Complex
Extracellular Space
Nucleus
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
Chromosome
Centrosome
STAGA Complex
Transcription Factor TFTC Complex
Oxoglutarate Dehydrogenase Complex
Mitotic Spindle
Molecular Function
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Transcription Factor Binding
H3 Histone Acetyltransferase Activity
Protein Phosphatase Binding
Histone Deacetylase Binding
Histone Acetyltransferase Activity (H4-K12 Specific)
Peptide-lysine-N-acetyltransferase Activity
Histone Succinyltransferase Activity
Histone Glutaryltransferase Activity
Biological Process
Activation Of MAPK Activity
Regulation Of Cytokine Production
Inflammatory Response
Signal Transduction
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Hippo Signaling
Cellular Response To Vascular Endothelial Growth Factor Stimulus
P38MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Transcription, DNA-templated
Cardiac Muscle Contraction
In Utero Embryonic Development
Somitogenesis
Cytokine Production
Neural Tube Closure
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Heart Development
Long-term Memory
Cell Population Proliferation
Response To Organic Cyclic Compound
Viral Process
Histone Acetylation
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Telencephalon Development
Metencephalon Development
Midbrain Development
Positive Regulation Of Cell Projection Organization
Regulation Of Protein Stability
Response To Nutrient Levels
Positive Regulation Of Histone Acetylation
Multicellular Organism Growth
Histone H3 Acetylation
Histone H4-K12 Acetylation
Histone H3-K14 Acetylation
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Gluconeogenesis
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Centriole Replication
Regulation Of Synaptic Plasticity
Intracellular Distribution Of Mitochondria
Regulation Of T Cell Activation
Limb Development
Regulation Of Cartilage Development
Cellular Response To Tumor Necrosis Factor
Alpha-tubulin Acetylation
Histone Succinylation
Peptidyl-lysine Glutarylation
Regulation Of Bone Development
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Oxidative Stress Induced Senescence
activated TAK1 mediates p38 MAPK activation
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HATs acetylate histones
Notch-HLH transcription pathway
B-WICH complex positively regulates rRNA expression
Ub-specific processing proteases
RNA Polymerase I Transcription Initiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Fostamatinib
Coenzyme A
Diseases
GWAS
Body mass index (
26426971
28892062
)
Coronary artery disease (
29212778
33020668
)
Inflammatory bowel disease (
26278503
)
Mean reticulocyte volume (
32888494
)
Vitiligo (
27723757
)
vWF and FVIII levels (
30586737
)
Interacting Genes
54 interacting genes:
AKT1
ALDOC
APP
ARAF
ARRB1
AURKA
BECN1
BRAF
CBLC
CCND2
CD44
CDC42
CDK4
CDK6
CDKN2B
CDKN2C
DCTN1
DYRK1B
ELK1
ERBB2
FZR1
GLIS2
HIF1A
KAT2A
KDELR2
LATS2
LRRK2
MAP2K5
MAP2K6
MAP3K2
MAP3K3
MAP3K4
MAPK12
MAPK14
MAPK3
MAPK8IP2
MET
NF1
NF2
NFIC
PLCB2
PTEN
RAF1
RASSF1
RPL13
SMAD1
SMAD7
STK11
TAOK1
TAOK2
TEAD2
TERT
TINF2
TP53
60 interacting genes:
AKT1
ATXN7
BATF2
BECN1
CCND2
CCNE1
CDK2
CDK6
CDKN2B
CEBPB
COMMD1
CREBBP
CRX
CTNNB1
CUL2
DTL
EID1
EP300
FZR1
GATA2
GRM1
H1-5
H2AC20
H2BC21
H3-4
H3C14
H4-16
H4C14
HSD11B2
IRF1
IRF2
IRF7
KDELR2
LATS2
MAP2K3
MAPK14
MYB
MYC
NF2
NOTCH1
PBX1
PPARG
PRKDC
PYGO2
RASSF1
RBPJ
RELA
SIRT2
STK11
TACC1
TACC2
TACC3
TADA2A
TCF3
TP53
TRRAP
TSC1
TTYH2
UBE2I
XRCC6
Entrez ID
5606
2648
HPRD ID
03816
03807
Ensembl ID
ENSG00000034152
ENSG00000108773
Uniprot IDs
P46734
Q6FI23
Q92830
PDB IDs
1F68
1Z4R
3D7C
5H84
5H86
5MLJ
5TRL
5TRM
6J3P
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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