IGSF21 and EPB41L3

Data Source:
HPRD (two hybrid)

		IGSF21	EPB41L3
Description		immunoglobin superfamily member 21	erythrocyte membrane protein band 4.1 like 3
Image		No pdb structure
GO Annotations	Cellular Component	Adherens Junction Anchored Component Of External Side Of Plasma Membrane Presynaptic Membrane Postsynaptic Membrane Inhibitory Synapse	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Cell Junction Axolemma Paranode Region Of Axon Juxtaparanode Region Of Axon
	Molecular Function		Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Maturation	Regulation Of Cell Growth Protein Localization To Paranode Region Of Axon Apoptotic Process Biological_process Regulation Of Cell Shape Cortical Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Paranodal Junction Assembly Actomyosin Structure Organization Myelin Maintenance Neuron Projection Morphogenesis Protein Localization To Juxtaparanode Region Of Axon Protein Localization To Plasma Membrane
Pathways			Neurexins and neuroligins
Drugs
Diseases
GWAS		Atypical femoral fracture in phosphonate treatment ( 31006051) Cobalt levels ( 26025379) Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Survival in pancreatic cancer ( 28470677)	Cerebral amyloid deposition (PET imaging) ( 26252872) Chronic kidney disease ( 31152163) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Glomerular filtration rate (creatinine) ( 28452372) Optic nerve head parameters (multi-trait analysis) ( 31798171) Sleep duration ( 25469926) Social communication problems ( 24564958) Thyroid nodules ( 30099483) Vertical cup-disc ratio ( 31798171)
Interacting Genes		32 interacting genes: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2	19 interacting genes: ATXN1L CADM1 CEP152 CLNS1A CNTNAP2 HSPB1 IGSF21 MBIP PAXIP1 PSEN1 SPANXN2 SPTBN1 TCF4 UNC13A YWHAB YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		84966	23136
HPRD ID		11309	05622
Ensembl ID		ENSG00000117154	ENSG00000082397
Uniprot IDs		Q96ID5	A0A0A0MRA8 A8K968 Q9Y2J2
PDB IDs			2HE7 3BIN 6IBE
Enriched GO Terms of Interacting Partners?
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