IGSF21 and DGKD

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IGSF21	DGKD
Description		immunoglobin superfamily member 21	diacylglycerol kinase delta
Image		No pdb structure
GO Annotations	Cellular Component	Adherens Junction Anchored Component Of External Side Of Plasma Membrane Presynaptic Membrane Postsynaptic Membrane Inhibitory Synapse	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit
	Molecular Function		NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Synapse Maturation	Phosphatidic Acid Biosynthetic Process Endocytosis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Response To Organic Substance Protein Transport Second-messenger-mediated Signaling Platelet Activation Intracellular Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Diacylglycerol Metabolic Process Lipid Phosphorylation Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Clathrin-dependent Endocytosis
Pathways			Effects of PIP2 hydrolysis
Drugs			Phosphatidyl serine alpha-Tocopherol succinate
Diseases
GWAS		Atypical femoral fracture in phosphonate treatment ( 31006051) Cobalt levels ( 26025379) Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171) Survival in pancreatic cancer ( 28470677)	Bilirubin levels ( 20639394 32084209) Calcium levels ( 24068962 29403010 20705733) Crohn's disease ( 22412388) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 32499647 30718926) Urinary calcium excretion ( 31993563)
Interacting Genes		32 interacting genes: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2	8 interacting genes: DGKH DYSF HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14
Entrez ID		84966	8527
HPRD ID		11309	03492
Ensembl ID		ENSG00000117154	ENSG00000077044
Uniprot IDs		Q96ID5	A0A024R495 Q16760
PDB IDs			1R79 3BQ7
Enriched GO Terms of Interacting Partners?
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