PTPN5 and VTI1B

Data Source:
BioGRID (two hybrid)

		PTPN5	VTI1B
Description		protein tyrosine phosphatase non-receptor type 5	vesicle transport through interaction with t-SNAREs 1B
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Platelet Alpha Granule Lumen SNARE Complex Early Endosome Membrane Late Endosome Membrane Vesicle Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Phosphatase Activity Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus	Platelet Degranulation Protein Targeting To Vacuole Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane
Pathways		Interleukin-37 signaling	Platelet degranulation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Myopia ( 27182965) Refractive error ( 32231278)	Blood protein levels ( 30072576)
Interacting Genes		19 interacting genes: CCNQ CLEC4G CUL5 CXCL9 CYB561D2 ENTPD3 FYN MAPK1 MAPK3 MARCHF5 MOB1A PRKN SLC35B1 SNX4 TERF1 TMEM201 TMEM51 VTI1B ZBTB5	35 interacting genes: AQP6 ASGR2 CD46 CD79A CLINT1 CRB3 CREB3 ERGIC3 FCGR1A GOLGB1 GPR35 GPX8 JAGN1 KASH5 KLRC1 KRTAP10-7 LDLRAD1 LMNA MANBAL PTPN5 REEP4 RNASEK SLC16A7 SLC35C2 STX1A STX2 STX4 STX7 STX8 SYNE4 TMEM14B TMEM234 TMEM51 TNK2 TRIM59
Entrez ID		84867	10490
HPRD ID		01472	04440
Ensembl ID		ENSG00000110786	ENSG00000100568
Uniprot IDs		B7Z2F8 P54829 Q86TL3	Q9UEU0
PDB IDs		2BIJ 2BV5 2CJZ 5OVR 5OVX 5OW1 6H8R	2V8S
Enriched GO Terms of Interacting Partners?
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