VTI1B and STX2

Data Source:
BioGRID (two hybrid)

		VTI1B	STX2
Description		vesicle transport through interaction with t-SNAREs 1B	syntaxin 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Platelet Alpha Granule Lumen SNARE Complex Early Endosome Membrane Late Endosome Membrane Vesicle Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane	Extracellular Space Plasma Membrane Synaptic Vesicle Endomembrane System Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium SNARE Complex Protein-containing Complex Intracellular Membrane-bounded Organelle Presynaptic Active Zone Membrane
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity	SNARE Binding Structural Molecule Activity SNAP Receptor Activity Protein Binding Calcium-dependent Protein Binding
	Biological Process	Platelet Degranulation Protein Targeting To Vacuole Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane	Intracellular Protein Transport Exocytosis Vesicle Fusion Signal Transduction Acrosome Reaction Ectoderm Development Animal Organ Morphogenesis Cell Differentiation Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Cellular Response To Oxidative Stress Vesicle Docking Cornified Envelope Assembly
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Initial pursuit acceleration in psychotic disorders ( 29064472) Metabolite levels ( 23823483) Plasma plasminogen activator levels ( 24578379) vWF levels ( 30586737)
Interacting Genes		35 interacting genes: AQP6 ASGR2 CD46 CD79A CLINT1 CRB3 CREB3 ERGIC3 FCGR1A GOLGB1 GPR35 GPX8 JAGN1 KASH5 KLRC1 KRTAP10-7 LDLRAD1 LMNA MANBAL PTPN5 REEP4 RNASEK SLC16A7 SLC35C2 STX1A STX2 STX4 STX7 STX8 SYNE4 TMEM14B TMEM234 TMEM51 TNK2 TRIM59	64 interacting genes: AARD ABI3 ANKRD46 APOL2 BET1 BLOC1S2 CD53 CDC23 CERT1 CPLX2 CTSA CYBC1 EBAG9 ENTPD3 FGA GET1 GIMAP5 MIP MRPL11 MTG1 NAPB NINJ2 PCGF2 PLN PLPP4 RMDN3 RNF4 RTP2 SEC22A SEC22B SERP1 SLC18A1 SNAP25 SNAP29 STRIT1 STX12 STX16 STX1A STX1B STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP5L SYT1 SYT4 SYT7 TMEM120A TMEM120B TSPAN8 UBE2I UNC13B VAMP2 VAMP3 VAMP5 VAPB VTI1B ZCCHC12 ZFPL1 ZNF785
Entrez ID		10490	2054
HPRD ID		04440	11816
Ensembl ID		ENSG00000100568	ENSG00000111450
Uniprot IDs		Q9UEU0	P32856
PDB IDs		2V8S
Enriched GO Terms of Interacting Partners?
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