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OGT and SIN3A
Data Source:
HPRD
(in vivo, in vitro)
OGT
SIN3A
Description
O-linked N-acetylglucosamine (GlcNAc) transferase
SIN3 transcription regulator family member A
Image
GO Annotations
Cellular Component
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Protein N-acetylglucosaminyltransferase Complex
Mitochondrial Membrane
Protein-containing Complex
Cell Projection
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Sin3 Complex
Transcription Repressor Complex
Molecular Function
Protein Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Acetylglucosaminyltransferase Activity
Protein N-acetylglucosaminyltransferase Activity
Protein O-GlcNAc Transferase Activity
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
Transcription Regulator Inhibitor Activity
Biological Process
Regulation Of Glycolytic Process
Regulation Of Gluconeogenesis
Regulation Of Transcription By RNA Polymerase II
Protein O-linked Glycosylation
Apoptotic Process
Signal Transduction
Response To Nutrient
Viral Process
Protein Processing
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Response To Insulin
Circadian Regulation Of Gene Expression
Regulation Of Rac Protein Signal Transduction
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Histone H4-K16 Acetylation
Positive Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Insulin Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Histone H3-K27 Methylation
Histone H3-K4 Trimethylation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Regulation Of Lipid Metabolic Process
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways
HATs acetylate histones
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
UCH proteinases
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Red cell distribution width (
32888494
)
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Interacting Genes
28 interacting genes:
CSNK2A1
CSNK2B
GSK3B
HCFC1
HIRA
HIVEP1
MAPT
MTDH
NUP62
NUP62CL
OGA
PHC3
PSG1
SAP30BP
SCAI
SIN3A
SNAP91
SP1
SRF
TAB1
TAB3
TET2
TRAF7
TRAK1
TRAK2
UBC
YES1
ZNF124
98 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
Entrez ID
8473
25942
HPRD ID
02222
09690
Ensembl ID
ENSG00000147162
ENSG00000169375
Uniprot IDs
O15294
Q96ST3
PDB IDs
1W3B
3PE3
3PE4
3TAX
4AY5
4AY6
4CDR
4GYW
4GYY
4GZ3
4GZ5
4GZ6
4N39
4N3A
4N3B
4N3C
4XI9
4XIF
5BNW
5C1D
5HGV
5LVV
5LWV
5NPR
5NPS
5VIE
5VIF
6E37
6EOU
6IBO
6MA1
6MA2
6MA3
6MA4
6MA5
6Q4M
6TKA
1PO4
Enriched GO Terms of Interacting Partners
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