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SIN3A and DDB1
Data Source:
BioGRID
(affinity chromatography technology, pull down)
SIN3A
DDB1
Description
SIN3 transcription regulator family member A
damage specific DNA binding protein 1
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Sin3 Complex
Transcription Repressor Complex
Chromosome, Telomeric Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Protein-containing Complex
Site Of Double-strand Break
Extracellular Exosome
Cul4-RING E3 Ubiquitin Ligase Complex
Molecular Function
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
Transcription Regulator Inhibitor Activity
DNA Binding
Damaged DNA Binding
Protein Binding
Protein-macromolecule Adaptor Activity
Protein-containing Complex Binding
WD40-repeat Domain Binding
Cullin Family Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Regulation Of Lipid Metabolic Process
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Proteasomal Protein Catabolic Process
Viral Process
Protein Ubiquitination
Nucleotide-excision Repair, DNA Incision
Histone H2A Monoubiquitination
DNA Damage Response, Detection Of DNA Damage
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of Viral Genome Replication
Positive Regulation Of Gluconeogenesis
Positive Regulation Of Protein Catabolic Process
Positive Regulation By Virus Of Viral Protein Levels In Host Cell
Rhythmic Process
Biological Process Involved In Interaction With Symbiont
Global Genome Nucleotide-excision Repair
UV-damage Excision Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Viral Release From Host Cell
Pathways
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Interacting Genes
98 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
44 interacting genes:
ABL1
BRAP
CNOT2
COPS2
COPS5
COPS8
CUL4A
CUL4B
DCAF11
DCAF8
DDB2
DET1
DNMT3A
DNMT3B
DTL
EME1
ERCC8
GPS1
GSPT1
H1-2
H3C1
HOXD3
IKZF1
IP6K1
LMO4
MEF2A
MUS81
PIN1
PTEN
RASSF1
SALL2
SIN3A
SIRT7
SKP2
STAT1
SUPT3H
SUV39H1
TP73
USP40
VAMP3
WDTC1
WIPI2
XPA
ZNF277
Entrez ID
25942
1642
HPRD ID
09690
10952
Ensembl ID
ENSG00000169375
ENSG00000167986
Uniprot IDs
Q96ST3
Q16531
PDB IDs
1PO4
2B5L
2B5M
2B5N
2HYE
3E0C
3EI1
3EI2
3EI3
3EI4
3I7H
3I7K
3I7L
3I7N
3I7O
3I7P
3I89
3I8C
3I8E
4A08
4A09
4A0A
4A0B
4A0K
4A0L
4A11
4CI1
4CI2
4CI3
4E54
4E5Z
4TZ4
5FQD
5HXB
5JK7
5V3O
6BN7
6BN8
6BN9
6BNB
6BOY
6DSZ
6FCV
6H0F
6H0G
6PAI
6Q0R
6Q0V
6Q0W
6R8Y
6R8Z
6R90
6R91
6R92
6SJ7
6TD3
6UD7
6UE5
6UML
Enriched GO Terms of Interacting Partners
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