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SIN3A and HDAC7
Data Source:
HPRD
(in vivo, two hybrid)
SIN3A
HDAC7
Description
SIN3 transcription regulator family member A
histone deacetylase 7
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Sin3 Complex
Transcription Repressor Complex
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
Transcription Regulator Inhibitor Activity
Protein Kinase C Binding
Protein Binding
Protein Kinase Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Activating Transcription Factor Binding
Metal Ion Binding
Repressing Transcription Factor Binding
14-3-3 Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Regulation Of Lipid Metabolic Process
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Protein Deacetylation
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Osteoblast Differentiation
Histone H3 Deacetylation
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of NIK/NF-kappaB Signaling
Pathways
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
SUMOylation of DNA damage response and repair proteins
Notch-HLH transcription pathway
Regulation of PTEN gene transcription
Drugs
Trichostatin A
Belinostat
Panobinostat
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31361310
30929738
32296059
)
Asthma (adult onset) (
31036433
30929738
)
Bipolar disorder (
31043756
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Conjunctival UV autofluorescence (CUVAF) (
25590795
)
Diastolic blood pressure (
27841878
)
Inflammatory bowel disease (
28067908
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Obesity-related traits (
23251661
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Primary sclerosing cholangitis (
23603763
)
Systolic blood pressure (
27841878
)
Ulcerative colitis (
28067908
)
Urate levels (
23263486
)
White blood cell count (
32888494
)
Interacting Genes
98 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
59 interacting genes:
ACOT11
ACTN4
ANTKMT
ARID5A
BCL6
BRWD1
C3orf36
CALCOCO2
CASP8
CDC42
CENPQ
DDIT4L
EDNRA
EGFR
ESM1
GNG12
GNMT
GOLGA6L9
HDAC1
HDAC2
HDAC3
HDAC4
HDAC5
KAT5
KLF16
KRBA2
LDB2
MARK2
MARK3
MEF2A
MEF2C
MEOX2
MIEN1
NCOR2
NME4
NRIP2
PATJ
PHC2
PPARD
PPP1R16A
PRKD1
PRKD2
RAC1
RAC2
RAC3
REL
RIPPLY1
RRAS2
RUNX2
SIN3A
SLC16A3
SOGA1
TIAF1
UBE2I
UBL3
YPEL3
YWHAG
YWHAQ
ZBTB16
Entrez ID
25942
51564
HPRD ID
09690
09133
Ensembl ID
ENSG00000169375
ENSG00000061273
Uniprot IDs
Q96ST3
Q8WUI4
PDB IDs
1PO4
3C0Y
3C0Z
3C10
3ZNR
3ZNS
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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