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SIN3A and TAL1
Data Source:
HPRD
(in vivo, in vitro)
SIN3A
TAL1
Description
SIN3 transcription regulator family member A
TAL bHLH transcription factor 1, erythroid differentiation factor
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Sin3 Complex
Transcription Repressor Complex
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Lsd1/2 Complex
Molecular Function
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
Transcription Regulator Inhibitor Activity
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Histone Deacetylase Binding
Protein Dimerization Activity
E-box Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Regulation Of Lipid Metabolic Process
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Locomotory Behavior
Spinal Cord Association Neuron Differentiation
Hemopoiesis
Erythrocyte Differentiation
Megakaryocyte Differentiation
Platelet Formation
Basophil Differentiation
Positive Regulation Of Protein-containing Complex Assembly
Embryonic Hemopoiesis
Megakaryocyte Development
Regulation Of Cell Population Proliferation
Erythrocyte Maturation
Cell Fate Commitment
Negative Regulation Of Erythrocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Chromatin Assembly Or Disassembly
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Division
Astrocyte Fate Commitment
Definitive Hemopoiesis
Hemangioblast Cell Differentiation
Hematopoietic Stem Cell Differentiation
Regulation Of Mast Cell Differentiation
Positive Regulation Of Protein Tyrosine Kinase Activity
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Signaling Receptor Activity
Pathways
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
Drugs
Diseases
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Adult body size (
32376654
)
Body mass index (
25673413
)
Clozapine-induced agranulocytosis (
25187353
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
)
Interacting Genes
98 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
23 interacting genes:
CHD3
DRG1
ELSPBP1
EP300
GATA1
GATA2
GATA3
HDAC1
HOXB9
KAT2B
KDM1A
LMO1
LMO2
MAPK3
NCAPG2
PRKCQ
SIN3A
SKP2
SP1
STUB1
TCF3
TCF4
ZHX1
Entrez ID
25942
6886
HPRD ID
09690
01753
Ensembl ID
ENSG00000169375
ENSG00000162367
Uniprot IDs
Q96ST3
P17542
Q16509
PDB IDs
1PO4
2YPA
2YPB
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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