MCM8 and MCM7

Data Source:
HPRD (in vivo)

		MCM8	MCM7
Description		minichromosome maintenance 8 homologous recombination repair factor	minichromosome maintenance complex component 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol MCM Complex MCM8-MCM9 Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Membrane MCM Complex CMG Complex
	Molecular Function	DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication Cellular Response To DNA Damage Stimulus Female Gamete Generation DNA Duplex Unwinding Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Protein Localization To Chromatin	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Population Proliferation Regulation Of Phosphorylation Response To Drug Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Breast cancer ( 29059683) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: FEM1C MCM4 MCM6 MCM7	77 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEP68 CHEK1 COG6 CRLS1 DBF4 DNAAF6 DUX4 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM55 TRIM63 UBE3A UBQLN1 USHBP1
Entrez ID		84515	4176
HPRD ID		12186	01154
Ensembl ID		ENSG00000125885	ENSG00000166508
Uniprot IDs		B4DN82 Q9UJA3	A0A0S2Z4A5 C6EMX8 P33993
PDB IDs		6L0O	6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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