MCM8

Description		minichromosome maintenance 8 homologous recombination repair factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol MCM Complex MCM8-MCM9 Complex
	Molecular Function	DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication Cellular Response To DNA Damage Stimulus Female Gamete Generation DNA Duplex Unwinding Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Protein Localization To Chromatin
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Breast cancer ( 29059683) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)
Interacting Genes		4 interacting genes: FEM1C MCM4 MCM6 MCM7
Entrez ID		84515
HPRD ID		12186
Ensembl ID		ENSG00000125885
Uniprot IDs		B4DN82 Q9UJA3
PDB IDs		6L0O
Enriched GO Terms of Interacting Partners?
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