MCM8 and MCM6

Data Source:
HPRD (in vivo)

		MCM8	MCM6
Description		minichromosome maintenance 8 homologous recombination repair factor	minichromosome maintenance complex component 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol MCM Complex MCM8-MCM9 Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex CMG Complex
	Molecular Function	DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication Cellular Response To DNA Damage Stimulus Female Gamete Generation DNA Duplex Unwinding Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Protein Localization To Chromatin	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Breast cancer ( 29059683) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)	Body mass index ( 25673413) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		4 interacting genes: FEM1C MCM4 MCM6 MCM7	38 interacting genes: C2CD6 CCNA1 CDC42 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 TRIM28 UBE3A ZBTB9
Entrez ID		84515	4175
HPRD ID		12186	03485
Ensembl ID		ENSG00000125885	ENSG00000076003
Uniprot IDs		B4DN82 Q9UJA3	Q14566
PDB IDs		6L0O	2KLQ 2LE8 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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