WDR83 and EGLN3

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		WDR83	EGLN3
Description		WD repeat domain 83	egl-9 family hypoxia inducible factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spliceosomal Complex Endosome Membrane Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity
	Biological Process	MAPK Cascade RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Response To Hypoxia Response To Lipopolysaccharide Regulation Of I-kappaB Kinase/NF-kappaB Signaling Inflammatory Response To Wounding	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Population Proliferation Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		MAP2K and MAPK activation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Ascorbic acid Roxadustat
Diseases
GWAS			Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		30 interacting genes: BAG2 BCL6 CRB3 CRK EGLN3 FAM124B FRS3 GNE GPKOW HNRNPH2 HOXA1 HSPB1 KCTD9 KDM1A KEAP1 LONRF1 LSM3 NOXA1 PARD6A PARD6B PCBP2 PRKAB2 RACK1 SAP30BP SF1 TLX3 TOE1 VAC14 WBP4 ZNF76	38 interacting genes: ABI2 ADRB2 ATF4 CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655
Entrez ID		84292	112399
HPRD ID		14730	06972
Ensembl ID		ENSG00000123154	ENSG00000129521
Uniprot IDs		Q9BRX9	B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9
PDB IDs
Enriched GO Terms of Interacting Partners?
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