CST6 and BCAR3

Data Source:
BioGRID (two hybrid)

		CST6	BCAR3
Description		cystatin E/M	BCAR3 adaptor protein, NSP family member
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GO Annotations	Cellular Component	Cornified Envelope Extracellular Exosome	Cytoplasm Focal Adhesion Membrane
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding
	Biological Process	Epidermis Development Anatomical Structure Morphogenesis Negative Regulation Of Endopeptidase Activity	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelin Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340) Serum uric acid levels ( 32514006)	Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)
Interacting Genes		7 interacting genes: BCAR3 GSK3B NOTCH2 PALB2 RAD51 TGFB1 YIF1A	38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GAS8 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45
Entrez ID		1474	8412
HPRD ID		03535	05268
Ensembl ID		ENSG00000175315	ENSG00000137936
Uniprot IDs		Q15828	A0A384MTS3 B3KNL6 B3KP06 O75815
PDB IDs		4N6L 4N6M 4N6N 4N6O 6FK0	3T6A
Enriched GO Terms of Interacting Partners?
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