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CASP7 and TERF1
Data Source:
BioGRID
(two hybrid)
CASP7
TERF1
Description
caspase 7
telomeric repeat binding factor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Spindle
Nuclear Body
Shelterin Complex
Molecular Function
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Microtubule Binding
DNA Binding, Bending
Telomeric DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Ankyrin Repeat Binding
G-rich Strand Telomeric DNA Binding
Biological Process
Proteolysis
Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Telomere Maintenance
Telomere Maintenance Via Telomerase
Cell Cycle
Negative Regulation Of DNA Replication
Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Cell Division
Negative Regulation Of Telomerase Activity
Telomeric D-loop Disassembly
T-circle Formation
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Shelterin Complex Assembly
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Exonuclease Activity
Negative Regulation Of Telomeric D-loop Disassembly
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Caspase-mediated cleavage of cytoskeletal proteins
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Fica
Emricasan
Incadronic acid
Diseases
GWAS
Smoking status (ever vs never smokers) (
30643258
)
Vitiligo (
27723757
22561518
)
Crohn's disease (
22412388
)
Leukocyte telomere length (
31171785
)
Interacting Genes
62 interacting genes:
AR
ARHGDIA
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
CASP10
CASP2
CASP3
CASP8
CASP9
CAST
CDC42
CFLAR
CLSPN
COPS6
CTSG
DCTN1
DFFA
DSP
EIF2AK2
GOLGA3
GORASP1
GZMB
HSPA5
KRT18
LYN
MAGEA11
MAPT
MAX
MEF2A
MEF2D
NEDD4
NIF3L1
PARP1
PLA2G4B
PRKCZ
PSEN1
PSEN2
PSIP1
PSME3
PTGES3
PTMA
RAC1
RAD21
RAD51
RASA1
RB1
RNF7
ROCK1
SAT1
SP1
SPTAN1
SRF
STAT1
STK24
TERF1
TNFRSF1A
UBE4B
VIM
XIAP
209 interacting genes:
ACAT2
ACOT7
ACY1
AFAP1L2
AHCY
AK1
AKR1A1
ALDOA
AMPD2
AMPH
ANXA2
ANXA5
ANXA8L1
APEX1
ARHGDIA
ARHGEF3
ARPP21
ASS1
ATM
BCL7B
BIN2
BLM
BRAF
C12orf43
C1orf35
CALD1
CAPNS1
CASP7
CCDC9
CDC6
CEP85
CFL1
CKB
CORO1B
CPNE3
CRYBB1
CRYM
DBN1
DBNL
DCX
DDX19B
DDX21
DDX23
DDX24
DDX39A
DLG5
DNAAF11
DNAJB1
DNPH1
DPP3
DPYSL3
EEF1D
EIF4B
ENO2
EPB41L1
EPHX2
EVL
FANCD2
FBP1
FBXO4
FEN1
FES
FKBP8
GAMT
GAPDH
GIT1
GNL3L
GNMT
GSS
H1-1
HCLS1
HDGFL2
HEXIM1
HEXIM2
HGD
HMGN3
HMGN4
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA6
IPO5
JSRP1
KCTD7
KDM1A
KEAP1
KIFBP
KLHDC4
KPNB1
LASP1
LDHA
LDHB
LRSAM1
LYAR
MAP4
MAP7
MAPK12
MAPRE1
MCM2
MDH1
MISP
MSN
MT1X
MVK
NAP1L1
NBN
NEFL
NEK7
NME1
NME2
NOL12
NOL3
NUDCD2
NUDT14
NUMA1
NXNL1
OCM2
OGFR
PA2G4
PACSIN2
PAFAH1B3
PAGE2
PAICS
PAK4
PCLAF
PCP4
PEPD
PFKP
PFN2
PGD
PGLS
PGM1
PGM2
PINX1
PKM
PNMT
POT1
PPM1G
PRDX1
PRDX6
PRKCB
PTMA
PTPN5
RBMY1A1
RECQL4
RIC8A
RLIM
RNF10
RPAP3
RPL19
RTN3
RTN4
SALL1
SARS1
SBDS
SENP8
SET
SH3BP1
SH3GL2
SH3GL3
SHFL
SIRPD
SKP1
SMAD9
SMARCC2
SNCG
SOAT1
SP100
SRM
SRSF6
STUB1
SULT1C2
SUPT5H
SYK
TALDO1
TBC1D10A
TBCD
TBL1X
TCIRG1
TERT
THG1L
TINAG
TINF2
TKT
TMSB10
TMSB4Y
TNKS
TNKS2
TNPO2
TOMM34
TPI1
TRIM16
TRIP10
TRMT1
TUBB2A
TUBB3
TUBB4B
UBE2M
UTP14A
WARS1
WDR4
WFS1
YWHAG
ZBTB16
ZC3H18
ZFP36L1
ZHX1
ZNF790
Entrez ID
840
7013
HPRD ID
03457
02975
Ensembl ID
ENSG00000165806
ENSG00000147601
Uniprot IDs
A0A0A0MRL7
B4DWA2
P55210
P54274
PDB IDs
1F1J
1GQF
1I4O
1I51
1K86
1K88
1KMC
1MIA
1SHJ
1SHL
2QL5
2QL7
2QL9
2QLB
2QLF
2QLJ
3EDR
3H1P
3IBC
3IBF
3R5K
4FDL
4FEA
4HQ0
4HQR
4JB8
4JJ8
4JR1
4JR2
4LSZ
4ZVO
4ZVP
4ZVQ
4ZVR
4ZVS
4ZVT
4ZVU
5IC6
5K20
5V6U
5V6Z
1BA5
1H6O
1ITY
1IV6
1W0T
3BQO
3L82
5HKP
5WIR
5XUP
Enriched GO Terms of Interacting Partners
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