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TERF1 and NME1
Data Source:
BioGRID
(two hybrid, pull down)
HPRD
(in vitro, two hybrid)
TERF1
NME1
Description
telomeric repeat binding factor 1
NME/NM23 nucleoside diphosphate kinase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Fibrillar Center
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Spindle
Nuclear Body
Shelterin Complex
Nucleus
Cytoplasm
Mitochondrial Outer Membrane
Centrosome
Cytosol
Intermediate Filament
Membrane
Ruffle Membrane
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
DNA Binding
Double-stranded Telomeric DNA Binding
Telomerase Activity
Protein Binding
Microtubule Binding
DNA Binding, Bending
Telomeric DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Ankyrin Repeat Binding
G-rich Strand Telomeric DNA Binding
Magnesium Ion Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
Single-stranded DNA Binding
RNA Binding
Deoxyribonuclease Activity
Nucleoside Diphosphate Kinase Activity
Protein Binding
ATP Binding
GTP Binding
Intermediate Filament Binding
Enzyme Binding
Identical Protein Binding
Gamma-tubulin Binding
Ribosomal Small Subunit Binding
Biological Process
Telomere Maintenance
Telomere Maintenance Via Telomerase
Cell Cycle
Negative Regulation Of DNA Replication
Telomere Capping
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Cell Division
Negative Regulation Of Telomerase Activity
Telomeric D-loop Disassembly
T-circle Formation
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Shelterin Complex Assembly
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Exonuclease Activity
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Myeloid Leukocyte Differentiation
Nucleoside Diphosphate Phosphorylation
GTP Biosynthetic Process
UTP Biosynthetic Process
CTP Biosynthetic Process
DNA Metabolic Process
Endocytosis
Lactation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Response To Amine
Nucleobase-containing Small Molecule Interconversion
Hippocampus Development
Cell Differentiation
Response To Testosterone
Cellular Response To Drug
Regulation Of Apoptotic Process
Positive Regulation Of DNA Binding
Positive Regulation Of Epithelial Cell Proliferation
Response To CAMP
Cellular Response To Glucose Stimulus
Cellular Response To Fatty Acid
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Interconversion of nucleotide di- and triphosphates
Drugs
Zinc
2'-Deoxyguanosine-5'-Triphosphate
Selenocysteine
2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate
Adenosine Phosphonoacetic Acid
Stavudine triphosphate
Thymidine-5'- Diphosphate
2'-Deoxyguanosine-5'-Diphosphate
2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate
Guanosine-5'-Diphosphate
3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate
Zidovudine diphosphate
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Crohn's disease (
22412388
)
Leukocyte telomere length (
31171785
)
Bipolar disorder (
31043756
)
Conjunctival UV autofluorescence (CUVAF) (
25590795
)
Metabolite levels (
23823483
)
Interacting Genes
209 interacting genes:
ACAT2
ACOT7
ACY1
AFAP1L2
AHCY
AK1
AKR1A1
ALDOA
AMPD2
AMPH
ANXA2
ANXA5
ANXA8L1
APEX1
ARHGDIA
ARHGEF3
ARPP21
ASS1
ATM
BCL7B
BIN2
BLM
BRAF
C12orf43
C1orf35
CALD1
CAPNS1
CASP7
CCDC9
CDC6
CEP85
CFL1
CKB
CORO1B
CPNE3
CRYBB1
CRYM
DBN1
DBNL
DCX
DDX19B
DDX21
DDX23
DDX24
DDX39A
DLG5
DNAAF11
DNAJB1
DNPH1
DPP3
DPYSL3
EEF1D
EIF4B
ENO2
EPB41L1
EPHX2
EVL
FANCD2
FBP1
FBXO4
FEN1
FES
FKBP8
GAMT
GAPDH
GIT1
GNL3L
GNMT
GSS
H1-1
HCLS1
HDGFL2
HEXIM1
HEXIM2
HGD
HMGN3
HMGN4
HMOX1
HNMT
HOXA3
HSP90AB1
HSPA6
IPO5
JSRP1
KCTD7
KDM1A
KEAP1
KIFBP
KLHDC4
KPNB1
LASP1
LDHA
LDHB
LRSAM1
LYAR
MAP4
MAP7
MAPK12
MAPRE1
MCM2
MDH1
MISP
MSN
MT1X
MVK
NAP1L1
NBN
NEFL
NEK7
NME1
NME2
NOL12
NOL3
NUDCD2
NUDT14
NUMA1
NXNL1
OCM2
OGFR
PA2G4
PACSIN2
PAFAH1B3
PAGE2
PAICS
PAK4
PCLAF
PCP4
PEPD
PFKP
PFN2
PGD
PGLS
PGM1
PGM2
PINX1
PKM
PNMT
POT1
PPM1G
PRDX1
PRDX6
PRKCB
PTMA
PTPN5
RBMY1A1
RECQL4
RIC8A
RLIM
RNF10
RPAP3
RPL19
RTN3
RTN4
SALL1
SARS1
SBDS
SENP8
SET
SH3BP1
SH3GL2
SH3GL3
SHFL
SIRPD
SKP1
SMAD9
SMARCC2
SNCG
SOAT1
SP100
SRM
SRSF6
STUB1
SULT1C2
SUPT5H
SYK
TALDO1
TBC1D10A
TBCD
TBL1X
TCIRG1
TERT
THG1L
TINAG
TINF2
TKT
TMSB10
TMSB4Y
TNKS
TNKS2
TNPO2
TOMM34
TPI1
TRIM16
TRIP10
TRMT1
TUBB2A
TUBB3
TUBB4B
UBE2M
UTP14A
WARS1
WDR4
WFS1
YWHAG
ZBTB16
ZC3H18
ZFP36L1
ZHX1
ZNF790
31 interacting genes:
APEX1
AURKA
CCND3
FBXO24
FXR2
GORASP2
ITGB1
KSR1
LNX1
MIF
NIF3L1
NME2
NME3
NME4
NTAQ1
NUTF2
PID1
POLR1C
PRUNE1
RAC1
RORA
RORB
RRAD
SET
SMARCD1
SOX30
SREK1IP1
TERF1
TIAM1
TNPO2
TNPO3
Entrez ID
7013
4830
HPRD ID
02975
01131
Ensembl ID
ENSG00000147601
ENSG00000239672
Uniprot IDs
P54274
A0A384MTW7
P15531
PDB IDs
1BA5
1H6O
1ITY
1IV6
1W0T
3BQO
3L82
5HKP
5WIR
5XUP
1JXV
1UCN
2HVD
2HVE
3L7U
4ENO
5UI4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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