TERF1 and NME2

Data Source:
HPRD (two hybrid, in vitro)

		TERF1	NME2
Description		telomeric repeat binding factor 1	NME/NM23 nucleoside diphosphate kinase 2
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Nuclear Body Shelterin Complex	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Intermediate Filament Focal Adhesion Lamellipodium Mitochondrial Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Ankyrin Repeat Binding G-rich Strand Telomeric DNA Binding	DNA Binding Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Serine/threonine Kinase Activity Fatty Acid Binding Protein Binding ATP Binding Drug Binding GDP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Cell Cycle Negative Regulation Of DNA Replication Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Cell Division Negative Regulation Of Telomerase Activity Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Exonuclease Activity Negative Regulation Of Telomeric D-loop Disassembly	Negative Regulation Of Myeloid Leukocyte Differentiation Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Positive Regulation Of Neuron Projection Development Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Cellular Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Epithelial Cell Proliferation Response To Growth Hormone Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Interconversion of nucleotide di- and triphosphates Neutrophil degranulation
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Crohn's disease ( 22412388) Leukocyte telomere length ( 31171785)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)
Interacting Genes		209 interacting genes: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 ANXA8L1 APEX1 ARHGDIA ARHGEF3 ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAAF11 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS H1-1 HCLS1 HDGFL2 HEXIM1 HEXIM2 HGD HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KCTD7 KDM1A KEAP1 KIFBP KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MISP MSN MT1X MVK NAP1L1 NBN NEFL NEK7 NME1 NME2 NOL12 NOL3 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCLAF PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS1 SBDS SENP8 SET SH3BP1 SH3GL2 SH3GL3 SHFL SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UBE2M UTP14A WARS1 WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790	18 interacting genes: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM
Entrez ID		7013	4831
HPRD ID		02975	01132
Ensembl ID		ENSG00000147601	ENSG00000243678
Uniprot IDs		P54274	F6XY72 P22392 Q6FHN3
PDB IDs		1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82 5HKP 5WIR 5XUP	1NSK 1NUE 3BBB 3BBC 3BBF
Enriched GO Terms of Interacting Partners?
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