TERF1 and ZFP36L1

Data Source:
BioGRID (two hybrid)

		TERF1	ZFP36L1
Description		telomeric repeat binding factor 1	ZFP36 ring finger protein like 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Nuclear Body Shelterin Complex	P-body Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Ankyrin Repeat Binding G-rich Strand Telomeric DNA Binding	DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Cell Cycle Negative Regulation Of DNA Replication Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Cell Division Negative Regulation Of Telomerase Activity Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Exonuclease Activity Negative Regulation Of Telomeric D-loop Disassembly	MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Vasculogenesis Proepicardium Development MRNA Processing Apoptotic Process Heart Development Cell Population Proliferation Response To Wounding Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Phosphatidylinositol 3-kinase Signaling Neural Tube Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of MRNA 3'-end Processing Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Multicellular Organism Growth P38MAPK Cascade Regulation Of MRNA Stability Protein Kinase B Signaling Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Monocyte Differentiation Regulation Of Myoblast Differentiation Mesendoderm Development MRNA Transport Chorio-allantoic Fusion 3'-UTR-mediated MRNA Destabilization ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Stem Cell Proliferation Cellular Response To Raffinose Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Keratinocyte Apoptotic Process Positive Regulation Of Intracellular MRNA Localization
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Leukocyte telomere length ( 31171785)	Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 31959851) Blond vs. brown/black hair color ( 30531825) Celiac disease ( 22057235 20190752 25920553) Crohn's disease ( 21102463) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure ( 30224653) Fibrinogen levels ( 28107422 26561523) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Inflammatory bowel disease ( 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 31511532) Multiple sclerosis ( 24076602 21833088) Nonsyndromic cleft lip ( 31609978) Prostate cancer ( 23535732) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		209 interacting genes: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 ANXA8L1 APEX1 ARHGDIA ARHGEF3 ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAAF11 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS H1-1 HCLS1 HDGFL2 HEXIM1 HEXIM2 HGD HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KCTD7 KDM1A KEAP1 KIFBP KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MISP MSN MT1X MVK NAP1L1 NBN NEFL NEK7 NME1 NME2 NOL12 NOL3 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCLAF PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS1 SBDS SENP8 SET SH3BP1 SH3GL2 SH3GL3 SHFL SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UBE2M UTP14A WARS1 WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790	9 interacting genes: ACD AKT1 MAPK14 MAPKAPK2 PAFAH1B2 POT1 TERF1 TINF2 YWHAB
Entrez ID		7013	677
HPRD ID		02975	03041
Ensembl ID		ENSG00000147601	ENSG00000185650
Uniprot IDs		P54274	A0A024R658 B3KNA8 Q07352
PDB IDs		1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82 5HKP 5WIR 5XUP	1W0V 1W0W
Enriched GO Terms of Interacting Partners?
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