CASP7 and PLA2G4B

Data Source:
BioGRID (enzymatic study)

		CASP7	PLA2G4B
Description		caspase 7	phospholipase A2 group IVB
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Extracellular Region Mitochondrial Inner Membrane Cytosol Early Endosome Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Proteolysis Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Inflammatory Response Parturition Arachidonic Acid Metabolic Process Calcium-mediated Signaling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling IRE1-mediated Unfolded Protein Response Glycerophospholipid Catabolic Process
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA XBP1(S) activates chaperone genes
Drugs		Fica Emricasan Incadronic acid
Diseases
GWAS		Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 27723757 22561518)
Interacting Genes		62 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP	5 interacting genes: CASP1 CASP3 CASP7 CASP8 HRAS
Entrez ID		840	100137049
HPRD ID		03457
Ensembl ID		ENSG00000165806	ENSG00000243708
Uniprot IDs		A0A0A0MRL7 B4DWA2 P55210	P0C869
PDB IDs		1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z
Enriched GO Terms of Interacting Partners?
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