PIP5K1A and ARF5

Data Source:
HPRD (in vitro)

		PIP5K1A	ARF5
Description		phosphatidylinositol-4-phosphate 5-kinase type 1 alpha	ADP ribosylation factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane	Cytoplasm Golgi Apparatus Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Phosphatidylinositol Phosphorylation Focal Adhesion Assembly Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle-mediated Transport
Pathways		Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Type 2 diabetes ( 23532257)
Interacting Genes		16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC	14 interacting genes: ACY3 AP1B1 AP3B1 ARFIP1 ARFIP2 ASAP2 DTX3 ERBB2 GGA1 GORAB IKBKG PIP5K1A RAB11A RAB11FIP3
Entrez ID		8394	381
HPRD ID		04470	00055
Ensembl ID		ENSG00000143398	ENSG00000004059
Uniprot IDs		A6PW57 Q99755	A4D0Z3 P84085
PDB IDs			2B6H
Enriched GO Terms of Interacting Partners?
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