ARF5 and PIP5K1A

Data Source:
HPRD (in vitro)

		ARF5	PIP5K1A
Description		ADP ribosylation factor 5	phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Plasma Membrane Focal Adhesion Nuclear Speck Lamellipodium Ruffle Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity Kinase Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle-mediated Transport	Glycerophospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phagocytosis Signal Transduction Phospholipid Biosynthetic Process Fibroblast Migration Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Keratinocyte Differentiation Actin Cytoskeleton Reorganization Phosphatidylinositol Phosphorylation Focal Adhesion Assembly Cell Chemotaxis Protein Localization To Plasma Membrane Activation Of GTPase Activity Ruffle Assembly
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Synthesis of PIPs at the plasma membrane PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Type 2 diabetes ( 23532257)	Body mass index ( 26426971)
Interacting Genes		14 interacting genes: ACY3 AP1B1 AP3B1 ARFIP1 ARFIP2 ASAP2 DTX3 ERBB2 GGA1 GORAB IKBKG PIP5K1A RAB11A RAB11FIP3	16 interacting genes: APP ARF1 ARF5 ARF6 BTK CADPS CASP3 KRAS MIR140 MIR34B NEDD4 PIP5KL1 PLD1 PLD2 RHOU TEC
Entrez ID		381	8394
HPRD ID		00055	04470
Ensembl ID		ENSG00000004059	ENSG00000143398
Uniprot IDs		A4D0Z3 P84085	A6PW57 Q99755
PDB IDs		2B6H
Enriched GO Terms of Interacting Partners?
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