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PIP5K1A and BTK
Data Source:
HPRD
(in vitro, in vivo)
PIP5K1A
BTK
Description
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha
Bruton tyrosine kinase
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Plasma Membrane
Focal Adhesion
Nuclear Speck
Lamellipodium
Ruffle Membrane
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cytoplasmic Vesicle
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
ATP Binding
1-phosphatidylinositol-4-phosphate 5-kinase Activity
Kinase Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
Glycerophospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Phagocytosis
Signal Transduction
Phospholipid Biosynthetic Process
Fibroblast Migration
Regulation Of Phosphatidylinositol 3-kinase Signaling
Cell Migration
Keratinocyte Differentiation
Actin Cytoskeleton Reorganization
Phosphatidylinositol Phosphorylation
Focal Adhesion Assembly
Cell Chemotaxis
Protein Localization To Plasma Membrane
Activation Of GTPase Activity
Ruffle Assembly
Positive Regulation Of Type III Hypersensitivity
Positive Regulation Of Type I Hypersensitivity
Negative Regulation Of Cytokine Production
Adaptive Immune Response
B Cell Affinity Maturation
Histamine Secretion By Mast Cell
Regulation Of B Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
G Protein-coupled Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Mesoderm Development
Peptidyl-tyrosine Phosphorylation
Calcium-mediated Signaling
Negative Regulation Of B Cell Proliferation
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
B Cell Activation
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Protein Autophosphorylation
Cell Maturation
B Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Molecule Of Fungal Origin
Apoptotic Signaling Pathway
Cellular Response To Interleukin-7
Pathways
Synthesis of PIPs at the plasma membrane
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
G alpha (q) signalling events
G alpha (12/13) signalling events
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
RHO GTPases Activate WASPs and WAVEs
G beta:gamma signalling through BTK
FCGR3A-mediated phagocytosis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Dasatinib
Inositol 1,3,4,5-Tetrakisphosphate
XL418
Ibrutinib
Acalabrutinib
Fostamatinib
Zanubrutinib
Abivertinib
Diseases
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Body mass index (
26426971
)
Interacting Genes
16 interacting genes:
APP
ARF1
ARF5
ARF6
BTK
CADPS
CASP3
KRAS
MIR140
MIR34B
NEDD4
PIP5KL1
PLD1
PLD2
RHOU
TEC
76 interacting genes:
ABL1
APP
AR
ARHGAP17
ARID3A
ARRB1
AURKA
BCL2L11
BECN1
BLNK
BMX
CAV1
CBL
CD19
CMTM3
COASY
DAPP1
ERBB3
EWSR1
FAS
FASLG
FYN
GAB1
GNA12
GNAQ
GNG2
GTF2I
HCK
IBTK
IRAK1
ITK
JAK1
KHDRBS1
KIT
LYN
MDM2
MEOX2
MET
MRPS22
MYD88
PIK3AP1
PIK3R3
PIP4K2A
PIP4K2B
PIP4K2C
PIP5K1A
PIP5K1B
PIP5K1C
PLAU
PLCG1
PLCG2
PRKCA
PRKCB
PRKCE
PRKCQ
PRKCZ
PRKD1
RELA
RPS6KB1
RPS6KB2
SH2B2
SH3BP5
SMURF1
STAT5A
SYK
TEC
TIRAP
TLR4
TLR6
TLR8
TLR9
TNFRSF10A
TP53
VAV1
WAS
WASF2
Entrez ID
8394
695
HPRD ID
04470
02248
Ensembl ID
ENSG00000143398
ENSG00000010671
Uniprot IDs
A6PW57
Q99755
Q06187
Q5JY90
PDB IDs
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2GE9
2Z0P
3GEN
3K54
3OCS
3OCT
3P08
3PIX
3PIY
3PIZ
3PJ1
3PJ2
3PJ3
4NWM
4OT5
4OT6
4OTF
4OTQ
4OTR
4RFY
4RFZ
4RG0
4RX5
4YHF
4Z3V
4ZLY
4ZLZ
5BPY
5BQ0
5FBN
5FBO
5J87
5JRS
5KUP
5P9F
5P9G
5P9H
5P9I
5P9J
5P9K
5P9L
5P9M
5T18
5U9D
5VFI
5VGO
5XYZ
5ZZ4
6AUA
6AUB
6BIK
6BKE
6BKH
6BKW
6BLN
6DI0
6DI1
6DI3
6DI5
6DI9
6E4F
6EP9
6HRP
6HRT
6HTF
6J6M
6N9P
6NFH
6NFI
6NZM
6O8I
6OMU
6S90
6TFP
6X3N
6X3O
6X3P
6XE4
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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