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PRKAB2 and CFP
Data Source:
BioGRID
(two hybrid)
PRKAB2
CFP
Description
protein kinase AMP-activated non-catalytic subunit beta 2
complement factor properdin
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleotide-activated Protein Kinase Complex
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Specific Granule Lumen
Collagen-containing Extracellular Matrix
Tertiary Granule Lumen
Molecular Function
AMP-activated Protein Kinase Activity
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Protein Binding
Biological Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Cell Cycle Arrest
Signal Transduction
Macroautophagy
Regulation Of Macroautophagy
Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Catalytic Activity
Regulation Of Primary Metabolic Process
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Signal Transduction By P53 Class Mediator
Immune Response
Complement Activation
Complement Activation, Alternative Pathway
Regulation Of Complement Activation
Defense Response To Bacterium
Neutrophil Degranulation
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
Alternative complement activation
Activation of C3 and C5
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
Neutrophil degranulation
Regulation of Complement cascade
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
GWAS
Interacting Genes
170 interacting genes:
ABHD11
ADAMTSL4
ANAPC11
ARID5A
AUNIP
AVP
BANP
BEND5
BHLHB9
BLZF1
C11orf1
C19orf54
C2orf42
C3orf36
CALCOCO2
CASP2
CASP6
CCDC28B
CCDC33
CDC14B
CDSN
CDX4
CFP
CREB3L1
CRX
CSNK2B
CYSRT1
DAO
DDAH2
DDIT4L
DICER1
DOK3
DST
ELL2
EPM2A
ESM1
FDX1
FLNC
GATA1
GATAD2B
GCSAML
GET4
GOLGA2
GOLGA6L9
GORASP2
GRAPL
GRN
GSC2
IHO1
IKZF1
IKZF3
IL37
IRAK1BP1
KATNBL1
KCTD5
KHDC4
KLF15
KRBOX4
KRT31
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP3-3
KRTAP4-12
KRTAP4-2
KRTAP4-5
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LHX3
LRIF1
LZTS1
LZTS2
MAGED1
MAJIN
MDFI
MEOX2
METTL27
MORN3
NAB2
NEBL
NHLRC4
NUTM1
OXER1
PDE6G
PDE6H
PFDN5
PIAS2
PNMA1
PPP1R13B
PPP1R16A
PRDM14
PRKAA1
PRKAG1
PRKAG2
PSMD11
PSME3
PYGM
QKI
RAB3IP
RACK1
RBM48
RBPMS
REL
RHEBL1
RIMBP3
RNF144B
ROR2
RPH3AL
SAMD4A
SERTAD2
SMARCB1
SMUG1
SPRY1
SPRY2
SSC4D
SSX2IP
STX11
STX19
TADA2A
TASOR2
TCF12
TCF19
TCF4
TCF7L2
TGM7
TLE5
TNNI1
TP53
TP53BP2
TRAF1
TRAF2
TRIB3
TRIM10
TRIM14
TRIM35
TRIM42
TRIM54
TRIM55
TRIM63
TSR2
TTC23
UBXN11
USP54
VBP1
VPS28
WDR83
YPEL3
YY1AP1
ZBTB32
ZC2HC1C
ZFP90
ZMYND19
ZNF177
ZNF236
ZNF474
ZNF526
ZNF559-ZNF177
ZNF581
32 interacting genes:
BANF2
C3
CFAP206
CFB
CYSRT1
FHL5
FKBP6
GEMIN4
GNE
HEXIM2
HOXA1
KCTD9
KLHL38
KRTAP11-1
KRTAP12-2
KRTAP3-1
KRTAP6-2
LCE1A
LONRF1
MID2
MTOR
NEK6
NOXA1
PRKAB2
RECK
SMARCC1
SPAG8
STK16
TRIP13
VENTX
ZNF330
ZNF414
Entrez ID
5565
5199
HPRD ID
04117
02308
Ensembl ID
ENSG00000131791
ENSG00000126759
Uniprot IDs
O43741
A0A0S2Z4I5
P27918
PDB IDs
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2YA3
4CFH
4EAI
4EAJ
4RER
4REW
6B2E
1W0R
1W0S
6RUR
6RUS
6RUV
6RV6
6S08
6S0A
6S0B
6SEJ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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