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PRKAB2 and ROR2
Data Source:
BioGRID
(two hybrid)
PRKAB2
ROR2
Description
protein kinase AMP-activated non-catalytic subunit beta 2
receptor tyrosine kinase like orphan receptor 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleotide-activated Protein Kinase Complex
Microtubule
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Dendrite
Clathrin-coated Endocytic Vesicle Membrane
Neuronal Cell Body
Receptor Complex
Molecular Function
AMP-activated Protein Kinase Activity
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Frizzled Binding
Protein Binding
ATP Binding
Wnt-protein Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Metal Ion Binding
Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
Biological Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Cell Cycle Arrest
Signal Transduction
Macroautophagy
Regulation Of Macroautophagy
Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Catalytic Activity
Regulation Of Primary Metabolic Process
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Signal Transduction By P53 Class Mediator
Cartilage Condensation
Somitogenesis
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Smoothened Signaling Pathway
JNK Cascade
Multicellular Organism Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Neuron Projection Development
Astrocyte Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Bone Mineralization
Positive Regulation Of Cell Migration
BMP Signaling Pathway
Embryonic Genitalia Morphogenesis
Male Genitalia Development
Positive Regulation Of Kinase Activity
Inner Ear Morphogenesis
Embryonic Digit Morphogenesis
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Cell Fate Commitment
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Synaptic Transmission, Glutamatergic
Wnt Signaling Pathway, Planar Cell Polarity Pathway
SMAD Protein Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Kinase C Activity
Macrophage Migration
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
PCP/CE pathway
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
Brachydactyly, including: type A; type B; type D; type E
Robinow syndrome
GWAS
Bipolar disorder (inflammation and infection response interaction) (
25781172
)
Bipolar disorder and schizophrenia (
22688191
)
Birth weight (
31043758
)
Bone mineral density (hip) (
26911590
)
Facial morphology (
31763980
)
Iris color (L* coordinate) (
30895295
)
Nose size (
27182965
)
Offspring birth weight (
31043758
)
Serum immune biomarker levels (
32066700
)
Type 2 diabetes (
25483131
)
Interacting Genes
170 interacting genes:
ABHD11
ADAMTSL4
ANAPC11
ARID5A
AUNIP
AVP
BANP
BEND5
BHLHB9
BLZF1
C11orf1
C19orf54
C2orf42
C3orf36
CALCOCO2
CASP2
CASP6
CCDC28B
CCDC33
CDC14B
CDSN
CDX4
CFP
CREB3L1
CRX
CSNK2B
CYSRT1
DAO
DDAH2
DDIT4L
DICER1
DOK3
DST
ELL2
EPM2A
ESM1
FDX1
FLNC
GATA1
GATAD2B
GCSAML
GET4
GOLGA2
GOLGA6L9
GORASP2
GRAPL
GRN
GSC2
IHO1
IKZF1
IKZF3
IL37
IRAK1BP1
KATNBL1
KCTD5
KHDC4
KLF15
KRBOX4
KRT31
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP3-3
KRTAP4-12
KRTAP4-2
KRTAP4-5
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LHX3
LRIF1
LZTS1
LZTS2
MAGED1
MAJIN
MDFI
MEOX2
METTL27
MORN3
NAB2
NEBL
NHLRC4
NUTM1
OXER1
PDE6G
PDE6H
PFDN5
PIAS2
PNMA1
PPP1R13B
PPP1R16A
PRDM14
PRKAA1
PRKAG1
PRKAG2
PSMD11
PSME3
PYGM
QKI
RAB3IP
RACK1
RBM48
RBPMS
REL
RHEBL1
RIMBP3
RNF144B
ROR2
RPH3AL
SAMD4A
SERTAD2
SMARCB1
SMUG1
SPRY1
SPRY2
SSC4D
SSX2IP
STX11
STX19
TADA2A
TASOR2
TCF12
TCF19
TCF4
TCF7L2
TGM7
TLE5
TNNI1
TP53
TP53BP2
TRAF1
TRAF2
TRIB3
TRIM10
TRIM14
TRIM35
TRIM42
TRIM54
TRIM55
TRIM63
TSR2
TTC23
UBXN11
USP54
VBP1
VPS28
WDR83
YPEL3
YY1AP1
ZBTB32
ZC2HC1C
ZFP90
ZMYND19
ZNF177
ZNF236
ZNF474
ZNF526
ZNF559-ZNF177
ZNF581
74 interacting genes:
ALG13
ARID5A
ATXN7L1
BHLHE40
C10orf55
C19orf54
C1orf94
C3orf56
CDC14A
CDC25C
CREM
CRX
DAB1
DAZAP2
DUSP1
DUSP10
DUSP14
DUSP18
DUSP19
DUSP21
DUSP29
DUSP6
ERBB2
EYA2
FAM168B
FOSB
FZD2
FZD5
HIVEP1
IKBKG
ILKAP
ISX
KRTAP19-7
KRTAP6-2
KRTAP7-1
LHX6
MAGED1
MAP3K7
MSX2
MTMR1
MTMR2
MTMR6
MTMR9
PITX1
PLA2G10
POU2AF1
PPM1A
PPM1B
PPM1F
PPP3CB
PRKAB2
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PTPN11
PTPN12
PTPN20
PTPN6
PTPN7
PTPRR
RBPMS
SOX14
STOX1
STYX
TAB1
TENT5A
TLX3
TPTE
VENTX
WNT5A
ZMYM4
ZNF34
Entrez ID
5565
4920
HPRD ID
04117
03822
Ensembl ID
ENSG00000131791
ENSG00000169071
Uniprot IDs
O43741
Q01974
PDB IDs
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2YA3
4CFH
4EAI
4EAJ
4RER
4REW
6B2E
3ZZW
4GT4
6OSH
6OSN
6OSV
Enriched GO Terms of Interacting Partners
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