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AXIN1 and LHX4
Data Source:
BioGRID
(two hybrid)
AXIN1
LHX4
Description
axin 1
LIM homeobox 4
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Cell Periphery
Chromatin
Nucleus
Molecular Function
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Methyl-CpG Binding
Sequence-specific DNA Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Multicellular Organism Development
Positive Regulation Of Peptidyl-threonine Phosphorylation
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Protein-containing Complex Assembly
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Placenta Development
Regulation Of Transcription By RNA Polymerase II
Motor Neuron Axon Guidance
Animal Organ Morphogenesis
Medial Motor Column Neuron Differentiation
Neuron Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Regulation of expression of SLITs and ROBOs
Drugs
1,4-Dithiothreitol
Diseases
Hepatocellular carcinoma
Caudal duplication anomaly
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Adult body size (
32376654
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Refractive error (
32231278
)
Interacting Genes
83 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TP53
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSGA10
USP7
UTP14A
ZBTB26
ZFYVE19
53 interacting genes:
ADAMTSL4
ARL2
AXIN1
BANP
BOD1L2
CDK3
CENPS-CORT
CHCHD2
CORO1B
DCAF10
DHRS1
DNAJB13
ERO1A
FDX2
GOLGA2
HOXC5
IFT172
IKZF1
INO80B
KLHL38
KRT38
KRT40
LDB1
LDB2
LONRF1
MAPRE3
MRS2
MYOZ1
NRF1
ORC6
PARP11
POU1F1
QRICH1
SCAND1
SH2D1A
SNRNP25
SNRPA
SSX1
TCAP
TCF4
TP53BP2
TRAPPC6A
TRMT11
TSEN54
TSTD2
TXNDC5
UBQLN1
USP2
WASHC3
YY1
ZBTB2
ZNF354C
ZNF76
Entrez ID
8312
89884
HPRD ID
04819
03686
Ensembl ID
ENSG00000103126
ENSG00000121454
Uniprot IDs
A0A0S2Z4R0
A0A0S2Z4S3
O15169
A0A0S2Z5S4
Q969G2
PDB IDs
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
5HOD
Enriched GO Terms of Interacting Partners
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