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AXIN1 and DVL1
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
AXIN1
DVL1
Description
axin 1
dishevelled segment polarity protein 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Cell Periphery
Cytosol
Microtubule
Postsynaptic Density
Lateral Plasma Membrane
Clathrin-coated Vesicle
Growth Cone
Cytoplasmic Vesicle
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Synapse
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Wnt Signalosome
Molecular Function
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
Molecular_function
Frizzled Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Identical Protein Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Multicellular Organism Development
Positive Regulation Of Peptidyl-threonine Phosphorylation
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Protein-containing Complex Assembly
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Neurotransmitter Levels
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Neurotransmitter Secretion
Axon Guidance
Heart Development
Neuromuscular Junction Development
Positive Regulation Of Neuron Projection Development
Neural Tube Development
Convergent Extension Involved In Neural Plate Elongation
Cytoplasmic Microtubule Organization
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Social Behavior
Protein Localization To Microtubule
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Receptor Clustering
Positive Regulation Of Transcription By RNA Polymerase II
Collateral Sprouting
Axon Extension
Dendrite Morphogenesis
Synapse Organization
Protein Stabilization
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Prepulse Inhibition
Dendritic Spine Morphogenesis
Skeletal Muscle Acetylcholine-gated Channel Clustering
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Presynapse Assembly
Positive Regulation Of Neuron Projection Arborization
Regulation Of Cellular Protein Localization
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Protein Localization To Presynapse
Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
PCP/CE pathway
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
1,4-Dithiothreitol
Diseases
Hepatocellular carcinoma
Caudal duplication anomaly
GWAS
Adult body size (
32376654
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Inflammatory bowel disease (
28067908
)
Nicotine dependence (
32281736
)
Ulcerative colitis (
28067908
)
Interacting Genes
83 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TP53
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSGA10
USP7
UTP14A
ZBTB26
ZFYVE19
43 interacting genes:
ANXA7
ARRB1
ATN1
AXIN1
BAG3
BRD7
BUB1
CCDC88C
CSNK1D
CSNK1E
CSNK2A1
CTNNB1
CXXC4
DAAM1
DAB2
DVL3
DYNLT1
EPS8
FBXW7
FRAT1
HDHD2
HECW1
KLHL12
LRRK2
MLH3
MSH2
NCK2
NEDD4
PPM1A
PSMA3
RAC1
RB1
SIPA1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
SMYD1
TRIM69
USP13
VANGL1
VANGL2
Entrez ID
8312
1855
HPRD ID
04819
03220
Ensembl ID
ENSG00000103126
ENSG00000107404
Uniprot IDs
A0A0S2Z4R0
A0A0S2Z4S3
O15169
O14640
PDB IDs
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
6TTK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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