SYN3 and PIAS2

Data Source:
BioGRID (two hybrid)

		SYN3	PIAS2
Description		synapsin III	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Synaptic Vesicle Postsynaptic Density Synaptic Vesicle Membrane Glutamatergic Synapse	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	ATP Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding SUMO Ligase Activity
	Biological Process	Neurotransmitter Secretion Regulation Of Synaptic Transmission, GABAergic Synaptic Vesicle Clustering	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819) Alzheimer's disease progression score ( 29860282) Benign prostatic hyperplasia ( 30988330) Blood protein levels ( 29875488 28240269) Chronic obstructive pulmonary disease ( 30804561) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Heel bone mineral density ( 30598549) Height ( 21998595 20881960 25282103 25429064 31562340) Interleukin-6 levels ( 22205395) Intracranial aneurysm ( 29531279) Intraocular pressure ( 29617998 29785010 31959993 30054594) Metabolite levels ( 23823483) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 31170924) Trunk fat mass adjusted for trunk lean mass ( 32239398)	Fruit consumption ( 32066663)
Interacting Genes		7 interacting genes: C9orf72 MORF4L1 MORF4L2 NOS1AP PIAS2 SYN1 SYN2	125 interacting genes: ACY3 ADA AKT1 AR ATF2 C1QA C5orf24 CBS CBSL CCHCR1 CCNDBP1 CDCA8 CGGBP1 CHMP4B CLDN2 CREB1 CREBBP CTBP1 DDX39B DES DEUP1 DMC1 DNMT3A EDC3 ELK1 ESR1 ESR2 EXOSC8 FAM118B FKBP6 FLI1 GFAP GLUL GOLGA2 GRHL2 GRM8 GTF2I GTF2IRD1 HDAC3 HMBOX1 HMG20A HMG20B HMGXB4 HNRNPCL1 HNRNPUL1 HOMER1 HOOK1 HUWE1 IKZF1 IMPDH1 JUN KIFC3 LCE1E LCE2C LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MLX MSX2 MX1 MX2 NAV2 NME7 NR3C1 PAICS PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 PRKRA PRPH RFX2 RUFY1 RUNX1T1 SEC23A SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SOX5 SPATC1L SPINDOC SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 SYN3 TH TICAM2 TP53 TRAF2 TRAF3 TRAF5 TRIM23 TRIM27 TRIM50 TRIM55 TRIM63 TSR2 TXLNA UBASH3B UBE2I UBE2L3 UBQLN1 ZBED1 ZBTB16 ZBTB8A ZC3H10 ZFP42 ZNF319 ZNF451 ZNRD2
Entrez ID		8224	9063
HPRD ID		04083	06944
Ensembl ID		ENSG00000185666	ENSG00000078043
Uniprot IDs		A0A024R1I8 O14994 Q17R54 Q59EX7	A0A024RC49 O75928 Q2TA77
PDB IDs		2P0A	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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