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LZTR1 and SREBF2
Data Source:
BioGRID
(two hybrid)
LZTR1
SREBF2
Description
leucine zipper like transcription regulator 1
sterol regulatory element binding transcription factor 2
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Endomembrane System
Cul3-RING Ubiquitin Ligase Complex
Recycling Endosome Membrane
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
SREBP-SCAP-Insig Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Small GTPase Binding
C-8 Sterol Isomerase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Protein Binding
Protein C-terminus Binding
Protein Dimerization Activity
E-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Protein Ubiquitination
Negative Regulation Of Ras Protein Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Cholesterol Metabolic Process
Regulation Of Notch Signaling Pathway
Cellular Response To Starvation
Positive Regulation Of Cholesterol Storage
SREBP Signaling Pathway
Cholesterol Homeostasis
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Pathways
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Regulation of cholesterol biosynthesis by SREBP (SREBF)
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Birth weight (
31043758
27680694
)
General cognitive ability (
29844566
)
Processed meat consumption (
32066663
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
55 interacting genes:
AATF
ANKRD53
ASB12
BMPR1B
CEBPZ
CHAF1A
CNOT6L
E2F8
EHMT1
FANK1
GABARAPL2
HCLS1
HDAC4
HRAS
IKBKG
KDM2B
KRAS
L3MBTL3
MCM3
MED16
MED7
MYBL2
NR1H3
NRAS
PAPOLG
PARP1
POLR1B
POLR2B
POLR2E
RAI1
RERE
RIT1
RUVBL1
SCMH1
SND1
SP100
SREBF2
SSX4
STAT1
SUGP2
TAF11
TBX2
TCF19
TFAP2B
TRIM5
TUBGCP4
WWP1
ZBTB1
ZNF137P
ZNF175
ZNF451
ZNF490
ZNF584
ZNF714
ZZZ3
50 interacting genes:
ABLIM1
ABLIM2
ARHGEF1
ARRB1
ATF7IP
ATXN1
AURKA
CASP3
CASP8AP2
COPS5
CREB1
CREBBP
EGR1
EP300
FHL2
FHL3
GOLGB1
HNF4A
HSPA5
INSIG1
INSIG2
ITGB4
KLF13
KPNB1
LINC00839
LZTR1
MAPK1
MAPK3
MRPS6
MTNR1B
NAE1
NFYA
NFYC
OS9
PIAS1
PIAS2
PIAS3
PSMD4
RAB11B
SCAP
SLC4A4
SMAD3
SP1
SPTBN1
SUMO1
TTC1
UBE2I
ZDHHC17
ZMYM2
ZYX
Entrez ID
8216
6721
HPRD ID
08992
02726
Ensembl ID
ENSG00000099949
ENSG00000198911
Uniprot IDs
A0A384NL67
Q8N653
A0A024R1Q0
Q12772
PDB IDs
1UKL
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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