LZTR1 and KDM2B

Data Source:
BioGRID (two hybrid)

		LZTR1	KDM2B
Description		leucine zipper like transcription regulator 1	lysine demethylase 2B
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Endomembrane System Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Membrane	Nucleus Nucleoplasm Nucleolus PcG Protein Complex
	Molecular Function	Protein Binding Small GTPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding RRNA Binding Histone Demethylase Activity Unmethylated CpG Binding Histone Demethylase Activity (H3-K36 Specific)
	Biological Process	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Protein Demethylation Spermatogenesis Midbrain-hindbrain Boundary Morphogenesis Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Initiation Of Neural Tube Closure Positive Regulation Of Cell Growth Forebrain Development Midbrain Development Hindbrain Development Histone H2A Monoubiquitination Negative Regulation Of Neuron Apoptotic Process Embryonic Camera-type Eye Morphogenesis Histone H3-K36 Demethylation Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			HDMs demethylate histones
Drugs
Diseases
GWAS			Adult body size ( 32376654) Hand grip strength ( 29691431) Lymphocyte percentage of white cells ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		55 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RIT1 RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	5 interacting genes: CEBPE FOS H3C1 LZTR1 UBE2D1
Entrez ID		8216	84678
HPRD ID		08992	12362
Ensembl ID		ENSG00000099949	ENSG00000089094
Uniprot IDs		A0A384NL67 Q8N653	B4DSN4 Q8NHM5
PDB IDs			4O64 5JH5 6BVA
Enriched GO Terms of Interacting Partners?
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