CANX and LCT

Data Source:
HPRD (in vivo)

		CANX	LCT
Description		calnexin	lactase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Melanosome Mitochondria-associated Endoplasmic Reticulum Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Unfolded Protein Binding	Lactase Activity Beta-glucosidase Activity Glycosylceramidase Activity
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Protein Secretion Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Protein Folding In Endoplasmic Reticulum Synaptic Vesicle Endocytosis Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Clathrin-dependent Endocytosis	Carbohydrate Metabolic Process Polysaccharide Digestion
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Digestion of dietary carbohydrate Intestinal saccharidase deficiencies
Drugs		Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	D-gluconhydroximo-1,5-lactam Nojirimycine Tetrazole alpha-D-Xylopyranose 2-deoxy-2-fluoro-Î±-D-glucose Gluconolactone (1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Diseases			Congenital lactase deficiency; Disaccharide intolerance II
GWAS		Daytime sleep phenotypes ( 27126917) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Resting heart rate ( 24680774) White blood cell count ( 32888494 27863252)	Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Lactose tolerance test ( 31791255) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Urinary metabolite levels in chronic kidney disease ( 31959995) White blood cell count ( 32888494)
Interacting Genes		47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	2 interacting genes: CANX HSPA5
Entrez ID		821	3938
HPRD ID		00252	04437
Ensembl ID		ENSG00000127022	ENSG00000115850
Uniprot IDs		P27824	P09848
PDB IDs
Enriched GO Terms of Interacting Partners?
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