LCT and CANX

Data Source:
HPRD (in vivo)

		LCT	CANX
Description		lactase	calnexin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Melanosome Mitochondria-associated Endoplasmic Reticulum Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse
	Molecular Function	Lactase Activity Beta-glucosidase Activity Glycosylceramidase Activity	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Unfolded Protein Binding
	Biological Process	Carbohydrate Metabolic Process Polysaccharide Digestion	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Protein Secretion Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Protein Folding In Endoplasmic Reticulum Synaptic Vesicle Endocytosis Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Clathrin-dependent Endocytosis
Pathways		Digestion of dietary carbohydrate Intestinal saccharidase deficiencies	Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		D-gluconhydroximo-1,5-lactam Nojirimycine Tetrazole alpha-D-Xylopyranose 2-deoxy-2-fluoro-Î±-D-glucose Gluconolactone (1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL	Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate
Diseases		Congenital lactase deficiency; Disaccharide intolerance II
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Lactose tolerance test ( 31791255) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Urinary metabolite levels in chronic kidney disease ( 31959995) White blood cell count ( 32888494)	Daytime sleep phenotypes ( 27126917) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Resting heart rate ( 24680774) White blood cell count ( 32888494 27863252)
Interacting Genes		2 interacting genes: CANX HSPA5	47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR
Entrez ID		3938	821
HPRD ID		04437	00252
Ensembl ID		ENSG00000115850	ENSG00000127022
Uniprot IDs		P09848	P27824
PDB IDs
Enriched GO Terms of Interacting Partners?
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