CANX and SLC2A1

Data Source:
HPRD (in vivo)

		CANX	SLC2A1
Description		calnexin	solute carrier family 2 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Melanosome Mitochondria-associated Endoplasmic Reticulum Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse	Golgi Membrane Photoreceptor Inner Segment Female Pronucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Intercalated Disc Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc Midbody Cortical Actin Cytoskeleton Sarcolemma Melanosome Extracellular Exosome Blood Microparticle Presynapse
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Unfolded Protein Binding	Long-chain Fatty Acid Transporter Activity Glucose Transmembrane Transporter Activity Protein Binding Kinase Binding Dehydroascorbic Acid Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity Protein Self-association D-glucose Transmembrane Transporter Activity
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Protein Secretion Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Protein Folding In Endoplasmic Reticulum Synaptic Vesicle Endocytosis Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Clathrin-dependent Endocytosis	Response To Hypoxia Lactose Biosynthetic Process Central Nervous System Development Female Pregnancy Regulation Of Glucose Transmembrane Transport Long-chain Fatty Acid Import Across Plasma Membrane L-ascorbic Acid Metabolic Process Cerebral Cortex Development Response To Insulin Cellular Response To Glucose Starvation Xenobiotic Transport Photoreceptor Cell Maintenance Regulation Of Insulin Secretion Protein-containing Complex Assembly Dehydroascorbic Acid Transport Cellular Response To Mechanical Stimulus Cellular Hyperosmotic Response Glucose Import Across Plasma Membrane Transport Across Blood-brain Barrier Response To Thyroglobulin Triiodothyronine Glucose Transmembrane Transport
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis
Drugs		Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	Resveratrol Carboxymethylcellulose
Diseases			GLUT1 deficiency syndrome (GLUT1DS); Glucose transport defect of the blood-brain barrier Primary torsion dystonia (PTD)
GWAS		Daytime sleep phenotypes ( 27126917) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Resting heart rate ( 24680774) White blood cell count ( 32888494 27863252)	Birth weight ( 31043758) Cardiac hypertrophy ( 21348951) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) White blood cell count ( 32888494)
Interacting Genes		47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	15 interacting genes: CALR CANX CCR2 COPS6 GAPDH GIPC1 GPR35 HSPB2 LTB4R2 PDIA3 PTK2B STOM SUMO1 UBE2I VHL
Entrez ID		821	6513
HPRD ID		00252	00683
Ensembl ID		ENSG00000127022	ENSG00000117394
Uniprot IDs		P27824	P11166 Q59GX2
PDB IDs			1SUK 4PYP 5EQG 5EQH 5EQI
Enriched GO Terms of Interacting Partners?
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