TLR10 and ECH1

Data Source:
HPRD (two hybrid)

		TLR10	ECH1
Description		toll like receptor 10	enoyl-CoA hydratase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Membrane Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Protein Binding Delta3,5-delta2,4-dienoyl-CoA Isomerase Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 10 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation
Pathways		Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane	Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31361310 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Blood protein levels ( 30072576) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
Interacting Genes		12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54	11 interacting genes: APP CSTF2 EEF1D EEF1G FAM9B HTT PAFAH1B3 SERPINB9 STAT3 TIMP1 TLR10
Entrez ID		81793	1891
HPRD ID		05884	02825
Ensembl ID		ENSG00000174123	ENSG00000104823
Uniprot IDs		A0A024R9W4 Q9BXR5	A0A384MR44 Q13011
PDB IDs		2J67	2VRE
Enriched GO Terms of Interacting Partners?
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