TLR10 and CAT

Data Source:
HPRD (two hybrid)

		TLR10	CAT
Description		toll like receptor 10	catalase
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Peroxisome Peroxisomal Membrane Peroxisomal Matrix Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane Protein-containing Complex Secretory Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Peroxisome Targeting Sequence Binding Aminoacylase Activity Catalase Activity Antioxidant Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding NADP Binding
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 10 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response	Response To Reactive Oxygen Species Osteoblast Differentiation Ureteric Bud Development Response To Hypoxia Protein Targeting To Peroxisome Triglyceride Metabolic Process Aging Cholesterol Metabolic Process Aerobic Respiration Response To Light Intensity UV Protection Response To Ozone Response To Lead Ion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Response To Inactivity Hemoglobin Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Estradiol Response To Insulin Response To Vitamin A Response To Vitamin E Response To L-ascorbic Acid Cellular Response To Oxidative Stress Response To Drug Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Response To Ethanol Response To Cadmium Ion Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Division Response To Hyperoxia Response To Fatty Acid Cellular Response To Growth Factor Stimulus Response To Phenylpropanoid Cellular Oxidant Detoxification
Pathways		Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane	Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Fomepizole Cannabidiol Medical Cannabis Nabiximols
Diseases			Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31361310 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54	8 interacting genes: ABL1 ABL2 APP EHHADH KEAP1 PTPN11 SUMO4 TLR10
Entrez ID		81793	847
HPRD ID		05884	00282
Ensembl ID		ENSG00000174123	ENSG00000121691
Uniprot IDs		A0A024R9W4 Q9BXR5	A0A384P5Q0 P04040
PDB IDs		2J67	1DGB 1DGF 1DGG 1DGH 1F4J 1QQW
Enriched GO Terms of Interacting Partners?
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