ECH1 and TLR10

Data Source:
HPRD (two hybrid)

		ECH1	TLR10
Description		enoyl-CoA hydratase 1	toll like receptor 10
Image
GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Delta3,5-delta2,4-dienoyl-CoA Isomerase Activity	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Protein Targeting To Peroxisome Fatty Acid Beta-oxidation	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Toll-like Receptor 10 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response
Pathways		Peroxisomal protein import Peroxisomal protein import	Toll Like Receptor 10 (TLR10) Cascade IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 31361310 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Helicobacter pylori serologic status ( 23652523) Limited cutaneous systemic scleroderma ( 29293537) Self-reported allergy ( 23817569) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		11 interacting genes: APP CSTF2 EEF1D EEF1G FAM9B HTT PAFAH1B3 SERPINB9 STAT3 TIMP1 TLR10	12 interacting genes: CAT ECH1 F8A1 FLNA FUT7 GLDC LUC7L3 MYD88 PTPN6 TLR1 TLR2 TRIM54
Entrez ID		1891	81793
HPRD ID		02825	05884
Ensembl ID		ENSG00000104823	ENSG00000174123
Uniprot IDs		A0A384MR44 Q13011	A0A024R9W4 Q9BXR5
PDB IDs		2VRE	2J67
Enriched GO Terms of Interacting Partners?
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